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Impact of long-term exposure to air pollution on myocardium ageing

Grant number: 16/23129-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2017
Effective date (End): February 28, 2019
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Paulo Hilário Nascimento Saldiva
Grantee:Ana Paula Cremasco Takano
Home Institution: Instituto de Estudos Avançados (IEA). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU), AP.TEM

Abstract

The long-term exposure to air pollution has an important impact in life expectancy of people living in large urban cities. Additionally, recent evidences indicate that air pollution seems to accelerate some cellular changes of natural aging process, which may cause or exacerbate many diseases not only limited to respiratory system diseases, but also those that target cardiovascular system and other organs and tissues. Many studies have demonstrated increased number of hospital admissions and mortality by cardiovascular causes associated to higher levels of air pollution. However, it has not been reported the influence of air pollution upon aging biomarkers in the myocardium. In this sense, the present study aim to determine the possible association between the long-term exposure to air pollution, assessed by quantification of pulmonary anthracosis, and the ageing myocardium of São Paulo city dwellers. The clinicopathologic approach by using autopsy of subjects that had lived in that large urban area will contribute to obtain information about the relationship between the ambient and cardiovascular disease-associated mechanisms. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CREMASCO TAKANO, ANA PAULA; JUSTO, LISIE TOCCI; DOS SANTOS, NATHALIA VILLA; MARQUEZINI, MONICA VALERIA; DE ANDRE, PAULO AFONSO; MONTEIRO DA ROCHA, FRANCISCO MARCELO; PASQUALUCCI, CARLOS AUGUSTO; BARROZO, LIGIA VIZEU; SINGER, JULIO M.; SALDIVA DE ANDRE, CARMEN DIVA; NASCIMENTO SALDIVA, PAULO HILARIO; VERAS, MARIANA MATERA. Pleural anthracosis as an indicator of lifetime exposure to urban air pollution: An autopsy-based study in Sao Paulo. Environmental Research, v. 173, p. 23-32, JUN 2019. Web of Science Citations: 0.

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