Impact of long-term exposure to air pollution on myocardium ageing

• Grant number: 16/23129-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date until: May 01, 2017
• End date until: February 28, 2019
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Paulo Hilário Nascimento Saldiva
• Grantee: Ana Paula Cremasco Takano
• Host Institution: Instituto de Estudos Avançados (IEA). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU), AP.TEM

Abstract

The long-term exposure to air pollution has an important impact in life expectancy of people living in large urban cities. Additionally, recent evidences indicate that air pollution seems to accelerate some cellular changes of natural aging process, which may cause or exacerbate many diseases not only limited to respiratory system diseases, but also those that target cardiovascular system and other organs and tissues. Many studies have demonstrated increased number of hospital admissions and mortality by cardiovascular causes associated to higher levels of air pollution. However, it has not been reported the influence of air pollution upon aging biomarkers in the myocardium. In this sense, the present study aim to determine the possible association between the long-term exposure to air pollution, assessed by quantification of pulmonary anthracosis, and the ageing myocardium of São Paulo city dwellers. The clinicopathologic approach by using autopsy of subjects that had lived in that large urban area will contribute to obtain information about the relationship between the ambient and cardiovascular disease-associated mechanisms. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CREMASCO TAKANO, ANA PAULA; JUSTO, LISIE TOCCI; DOS SANTOS, NATHALIA VILLA; MARQUEZINI, MONICA VALERIA; DE ANDRE, PAULO AFONSO; MONTEIRO DA ROCHA, FRANCISCO MARCELO; PASQUALUCCI, CARLOS AUGUSTO; BARROZO, LIGIA VIZEU; SINGER, JULIO M.; SALDIVA DE ANDRE, CARMEN DIVA; et al. Pleural anthracosis as an indicator of lifetime exposure to urban air pollution: An autopsy-based study in Sao Paulo. Environmental Research, v. 173, p. 23-32, JUN 2019. (16/22793-0, 16/23129-7, 16/03461-7, 13/21728-2)

DOS SANTOS, NATHALIA VILLA; VIEIRA, CAROLINA LETICIA ZILLI; SALDIVA, PAULO HILARIO NASCIMENTO; DE ANDRE, CARMEN DIVA SALDIVA; MAZZILLI, BARBARA PACI; ANDRADE, MARIA DE FATIMA; SAUEIA, CATIA HELOISA; SAIKI, MITIKO; VERAS, MARIANA MATERA; KOUTRAKIS, PETROS. Accumulation of trace element content in the lungs of Sao Paulo city residents and its correlation to lifetime exposure to air pollution. SCIENTIFIC REPORTS, v. 12, n. 1, p. 7-pg., 2022-06-30. (16/22793-0, 13/21728-2, 16/03461-7, 16/23129-7)

DOS SANTOS, NATHALIA VILLA; ZILLI VIEIRA, CAROLINA LETICIA; NASCIMENTO SALDIVA, PAULO HILARIO; MAZZILLI, BARBARA PACI; SAIKI, MITIKO; SAUEIA, CATIA HELOISA; SALDIVA DE ANDRE, CARMEN DIVA; JUSTO, LISIE TOCCI; NISTI, MARCELO BESSA; KOUTRAKIS, PETROS. Levels of Polonium-210 in brain and pulmonary tissues: Preliminary study in autopsies conducted in the city of Sao Paulo, Brazil. SCIENTIFIC REPORTS, v. 10, n. 1, JAN 13 2020. (13/21728-2, 16/03461-7, 16/22793-0, 16/23129-7)