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Analysis of lipid metabolism after immunological scar induced by acute gastrointestinal infection

Grant number: 17/02298-8
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2017
Effective date (End): August 31, 2019
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Denise Morais da Fonseca
Grantee:Mirian Krystel de Siqueira
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:15/25364-0 - Impact of infection-induced immunological scarring on the long-term host metabolic homeostasis, AP.JP
Associated scholarship(s):18/14562-4 - Contribution of gut microbiota for the metabolic changes induced by acute infection with Yersinia pseudotuberculosis, BE.EP.MS


In recent years, the world has experienced an epidemic of obesity that affects populations in different ages living at different areas of the globe. Obesity, diabetes, cardiovascular diseases and metabolic diseases, in general, are considered complex diseases because they have a multifactorial etiology. For many years the etiology of such diseases has been associated with a combination of genetic and environmental factors (mainly feeding). However, we now know that there is a very important immunological component for the pathogenesis of such diseases, particularly with regard to the immune system associated with the intestinal mucosa. The intestinal microbiota plays an active role both in the digestion and absorption of nutrients and in the local and systemic regulation of the immune system. It is known that breaking the microbiota / host balance may trigger the development of inflammatory bowel diseases, allergies and environmental enteropathies. Recent works have evidenced an important connection between the immune system and microorganisms present in the intestine in the development of obesity, cardiovascular diseases and metabolic syndromes. Changes in the composition of the intestinal microbiota may interfere with host metabolism. In this way, it is possible that infections of the gastrointestinal tract that have an impact on the microorganism-immune system homeostasis cause the development of metabolic diseases. In a recent study by our group, we have shown that acute infections can irreparably damage tissues and such lesions are maintained by components of the intestinal microbiota. After control of the experimental infection by Yersinia pseudotuberculosis, mice develop permanent lesion of the mesenteric lymphatic vessels. Since mesenteric lymph vessels have a crucial function for the absorption and transport of lipids, these lesions are characterized by increased lymphatic permeability and chylomicron accumulation in the peritoneal cavity (chylous ascites). This phenomenon may substantially interfere with the metabolic capacity of the host, either by altering the route of lipid transport or by inducing local inflammation, since lymph containing chylomicrons has pro-inflammatory and adipogenic properties. Thus, the objective of this project is to evaluate the lipid absorption and metabolism after acute intestinal infection by Y. pseudotuberculosis. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SIQUEIRA, Mirian Krystel de. Metabolic imprint after immunological scar induced by acute gastrointestinal infection. 2019. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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