Impact of age in radiation-induced oral toxicities of young patients with oral cancer

• Grant number: 16/22862-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): June 01, 2017
• Effective date (End): May 31, 2018
• Field of knowledge: Health Sciences - Dentistry - Dental Clinics
• Principal Investigator: Alan Roger dos Santos Silva
• Grantee: Jaqueline de Lima Correia
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

An increase in the incidence of oral squamous cell carcinomas (OSCC) in patients younger than 45 years old has been demonstrated worldwide. However, the scenario of young patients with oral cancer is still controversial, which limits the comprehension of its pathogenesis, biological behavior of tumors and patients prognosis. Hence, there is a lack of well-defined cancer treatment protocols in this context. Similarly, the impact of age in the risk for developing radiation-related oral toxicities is also unknown. Objectives: Determine the incidence and the severity of oral toxicities associated with radiotherapy (RT) in young patients with OSCC. Material and methods: Observational clinical study, retrospective, controlled, involving patients diagnosed with OSCC who completed RT and received dental support from the Service of Dental Oncologic at the São Paulo State Cancer Institute (ICESP), from December 2013 to December 2016. The patients will be distributed into two groups: young (<45 years old, n=20) and elderly (>60 years old, n=20) and paired according to tumor location, clinical stage of disease and cancer treatment modality. Demographic information and clinicopathological data concerning acute oral toxicities will be collected relative to the 7th, 21st and 35th days of RT, with emphasis to the following clinical outcomes: oral mucositis, xerostomia, trismus, dysgeusia, dysphagia, pain, opportunistic infections and radiodermitis, according to the Common Terminology Criteria for Adverse Events version 4.0 and the World Health Organization (1979). Expected Results: Contribute to the better understanding of the problematic of side effects of cancer treatment in young patients with oral cancer.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PALMIER, NATALIA RANGEL; MIGLIORATI, CESAR AUGUSTO; PRADO-RIBEIRO, ANA CAROLINA; QUERIDO DE OLIVEIRA, MARIA CECILIA; VECHIATO FILHO, ALJOMAR JOSE; DE GOES, MARIO FERNANDO; BRANDAO, THAIS BIANCA; LOPES, MARCIO AJUDARTE; SANTOS-SILVA, ALAN ROGER. Radiation-related caries: current diagnostic, prognostic, and management paradigms. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 130, n. 1, p. 52-62, JUL 2020. (18/02233-6, 12/06138-1, 13/18402-8, 16/22862-2, 18/04657-8)

MORAIS-FARIA, KARINA; PALMIER, NATALIA RANGEL; CORREIA, JAQUELINE DE LIMA; DE CASTRO JUNIOR, GILBERTO; DIAS, REINALDO BRITO; PINTO, HENRIQUE DA GRACA; LOPES, MARCIO AJUDARTE; PRADO RIBEIRO, ANA CAROLINA; BRANDAO, THAIS BIANCA; SANTOS-SILVA, ALAN ROGER. Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus. SUPPORTIVE CARE IN CANCER, v. 28, n. 9, p. 4345-4352, SEP 2020. (18/02233-6, 16/22862-2, 18/04657-8)

PALMIER, NATALIA RANGEL; PAES LEME, ADRIANA FRANCO; DE ROSSI, TATIANE; TELLES, GUILHERME PIMENTEL; MORAIS-FARIA, KARINA; KOWALSKI, LUIZ PAULO; MARTA, GUSTAVO NADER; BRANDAO, THAIS BIANCA; ARANY, PRAVEEN R.; MIGLIORATI, CESAR AUGUSTO; et al. Salivary alpha-1-antitrypsin and macrophage migration inhibitory factor may be potential prognostic biomarkers for oncologic treatment-induced severe oral mucositis. SUPPORTIVE CARE IN CANCER, v. 29, n. 6, p. 2939-2946, JUN 2021. (18/04657-8, 15/12431-1, 12/06138-1, 13/18402-8, 16/22862-2, 16/07846-0, 18/02233-6)

MARTINS, BEATRIZ NASCIMENTO FIGUEIREDO LEBRE; PALMIER, NATALIA RANGEL; PRADO-RIBEIRO, ANA CAROLINA; DE GOES, MARIO FERNANDO; LOPES, MARCIO AJUDARTE; BRANDA, THAIS BIANCA; RIVERA, CESAR; MIGLIORATI, CESAR AUGUSTO; EPSTEIN, JOEL B.; SANTOS-SILVA, ALAN ROGER. Awareness of the risk of radiation-related caries in patients with head and neck cancer: A survey of physicians, dentists, and patients. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 132, n. 4, p. 398-408, OCT 2021. (16/22862-2, 13/18402-8, 12/06138-1, 18/04657-8, 18/02233-6)