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In vitro bioaccessibility assessment and in vivo bioavailability of arsenic ingested through rice commonly consumed by Brazilians

Grant number: 16/19924-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2017
Effective date (End): May 31, 2020
Field of knowledge:Health Sciences - Pharmacy
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Bruno Lemos Batista
Grantee:Tatiana Pedron
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated research grant:14/05151-0 - Arsenic and rice: monitoring and (bio)remediation studies for food safety, AP.JP


Essential elements such as arsenic (As) are detected in rice grains in several regions of the world, which may pose risks to human health because it is a toxic element even at low concentrations. Once rice cultivated under anaerobic conditions (flooded system) absorb about 4 times more As than under aerobic conditions (highlands). This accumulation is an issue of concerning once As is carcinogenic to humans. Several studies have been conducted to determine the As concentrations not only in rice but in many foods rice-containing. In humans, the main site of As uptake is the gastrointestinal tract once the main route of exposure are foods. Into the human body, As can be biotrasformed by the gastrointestinal cells or metabolized by the liver and thus conducted by the bloodstream to other organs and tissues causing deleterious effects. There are several studies in vitro and in vivo involving animals, however tests involving humans are scarcely. Evaluation of As effects on humans through rice naturally contaminated is important, since many factors can influence the bioavailability of As. Therefore, this project aims to evaluate the in vitro bioaccessibility and in vivo bioavailability in volunteers under rice-diet commonly consumed by Brazilians (purchased from supermarket). (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEDRON, TATIANA; FREIRE, BRUNA MOREIRA; CASTRO, CARLOS EDUARDO; RIBAL, LUIZ FELIPE; BATISTA, BRUNO LEMOS. Availability of arsenic in rice grains by in vitro and in vivo (humans) assays. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, v. 56, p. 184-191, DEC 2019. Web of Science Citations: 0.
PEDRON, TATIANA; SEGURA, FABIANA ROBERTA; PANIZ, FERNANDA POLIO; SOUZ, FELIPE DE MOURA; DOS SANTOS, MAURO COELHO; DE MAGALHAES JUNIOR, ARIANO MARTINS; BATISTA, BRUNO LEMOS. Mitigation of arsenic in rice grains by polishing and washing: Evidencing the benefit and the cost. JOURNAL OF CEREAL SCIENCE, v. 87, p. 52-58, MAY 2019. Web of Science Citations: 0.
SOUZA, FELIPE DE MOURA; PANIZ, FERNANDA POLLO; PEDRON, TATIANA; DOS SANTOS, MAURO COELHO; BATISTA, BRUNO LEMOS. A high-throughput analytical tool for quantification of 15 metallic nanoparticles supported on carbon black. HELIYON, v. 5, n. 3 MAR 2019. Web of Science Citations: 1.
PANIZ, FERNANDA POLLO; PEDRON, TATIANA; FREIRE, BRUNA MOREIRA; TORRES, DAIANE PLACIDO; SILVA, FABIO FERREIRA; BATISTA, BRUNO LEMOS. Effective procedures for the determination of As, Cd, Cu, Fe, Hg, Mg, Mn, Ni, Pb, Se, Th, Zn, U and rare earth elements in plants and foodstuffs. ANALYTICAL METHODS, v. 10, n. 33, p. 4094-4103, SEP 7 2018. Web of Science Citations: 4.

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