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Biotransformation of cubebin and hardwickiic acid by Cunninghamella echinulata and biological activities evaluation

Grant number: 17/02592-3
Support type:Scholarships in Brazil - Master
Effective date (Start): June 01, 2017
Effective date (End): February 28, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Sergio Ricardo Ambrosio
Grantee:Larissa Costa Oliveira
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
Associated research grant:11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species, AP.TEM


Natural products biotransformation by filamentous fungi are an interesting strategy to obtain new derivatives compounds with biological activities. These new analogs compounds could be used in structure/activity relationship studies, directing the production of compounds with higher pharmacological potential or less toxicity compared with original compound and metabolism studies of xenobiotics. Cunninghamella genus has been used in several biotransformation studies due to the complete or partial mimic capacity of hepatic mammals metabolism. The hardwickiic acid, an diterpene found in oleoresins of Copaifera trees, have been demonstrated antimicrobial activity, oxide nitric inhibition and presynaptic opioid receptors modulation. Cubebin, an lignan present in Piper cubeba seeds, have been demonstrated many biological activities as anti-inflammatory, antioxidant, antitumor, trypanocidal, leishmanicidal, antimicrobial and erectile dysfunction. Biotransformation of these compounds could result in new bioactive analogs and contributions to the knowledge of hepatic metabolism of these hardwickiic acid and cubebin. (AU)