Biotransformation of cubebin and hardwickiic acid by Cunninghamella echinulata and biological activities evaluation

• Grant number: 17/02592-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2017
• End date: February 28, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Sergio Ricardo Ambrosio
• Grantee: Larissa Costa Oliveira
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated research grant: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species, AP.TEM

Abstract

Natural products biotransformation by filamentous fungi are an interesting strategy to obtain new derivatives compounds with biological activities. These new analogs compounds could be used in structure/activity relationship studies, directing the production of compounds with higher pharmacological potential or less toxicity compared with original compound and metabolism studies of xenobiotics. Cunninghamella genus has been used in several biotransformation studies due to the complete or partial mimic capacity of hepatic mammals metabolism. The hardwickiic acid, an diterpene found in oleoresins of Copaifera trees, have been demonstrated antimicrobial activity, oxide nitric inhibition and presynaptic opioid receptors modulation. Cubebin, an lignan present in Piper cubeba seeds, have been demonstrated many biological activities as anti-inflammatory, antioxidant, antitumor, trypanocidal, leishmanicidal, antimicrobial and erectile dysfunction. Biotransformation of these compounds could result in new bioactive analogs and contributions to the knowledge of hepatic metabolism of these hardwickiic acid and cubebin. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA, LARISSA COSTA; PORTO, THIAGO SOUZA; COLMANETTE JUNIOR, ARTHUR HENRIQUE; CONCEICAO SANTOS, MARIO FERREIRA; RAMOS, HENRIQUE PEREIRA; BRAUN, GLAUCIA HOLLAENDER; DE LIMA PAULA, LUCAS ANTONIO; BASTOS, JAIRO KENUPP; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI; TAME PARREIRA, RENATO LUIS; et al. Schistosomicidal activity of kaurane, labdane and clerodane-type diterpenes obtained by fungal transformation. Process Biochemistry, v. 98, p. 34-40, NOV 2020. (11/13630-7, 11/21638-8, 17/02592-3)