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Effects of mate tea associated or not with strength training on bone tissue of Wistar rats in the growth phase

Grant number: 17/05069-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Rita Cássia Menegati Dornelles
Grantee:Adailton Jose dos Santos Silva
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Although the effects of osteoporosis are observed mainly in the aging phase, it is known that there are strategies for the prevention of osteoporosis by concentrating on the maximization of bone mass during growth and maturation, thus minimizing bone loss during life. Some natural products with antioxidant activity have been tested and used to minimize bone loss. Mate tea (MT), a beverage with antioxidant properties, is associated with the reduction of reactive oxygen species and an increase in bone mineral density. Physical exercise has also been considered as a strategy capable of improving the enzymatic antioxidant activity, besides, it is consensus in the literature the effectiveness in promoting improvement in quality and bone mass. Although there is evidence on the efficacy of phytochemicals and physical exercise in response to oxidative stress, it is still complex if the association of both can interact positively by improving the quality of bone tissue during the growth phase. Therefore, the objective of the present study is to analyze the effects of strength training (ST) and / or mate tea (MT) on the quality of bone tissue. Based on this, 32 Wistar rats with initial age of 3 months will be used, which will be distributed in the following experimental groups: NT (untrained), NT + MT (untrained + mate tea), ST (strength training), ST + MT (training + mate tea), consisting of 8 animals each. Changes in trabecular and cortical structure of bone tissue, BMD, alterations in biomechanical properties and evaluation of antioxidant capacity and oxidative stress in bone tissue will be evaluated. (AU)

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