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The Role of Methylation in the Melanoma Initiation and Progression and the Epigenetic Impact in vitro

Grant number: 17/09612-0
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): November 06, 2017
Effective date (End): November 05, 2018
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Vinicius de Lima Vazquez
Grantee:Anna Luiza Silva Almeida Vicente
Supervisor: Zdenko Herceg
Host Institution: Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil
Research place: International Agency for Research on Cancer (IARC), France  
Associated to the scholarship:16/15941-3 - The Role of Methylation in the Melanoma Initiation and Progression and the Epigenetic Impact in vitro, BP.DR


The proposal of the main study is to interrogate the epigenetic role in melanoma initiation and progression. The International Agency for Research on Cancer (IARC) is an intergovernmental agency that is part of the World Health Organization (WHO). Dr Zdenko Herceg is the principal investigator of the Epigenetics Group at IARC. His group has a great expertise in the epigenetic analysis of tumors, including high throughput techniques and bioinformatics analysis. In this context, a collaboration between Barretos Cancer Hospital and IARC was established, in order to perform at IARC, the first part of the project consisting in the methylation profiling of 100 melanoma cases previously analyzed for genomic alteration by whole-genome-sequencing and included in the International Cancer Genome Consortium (ICGC), followed by bioinformatics analysis and clinical-pathological associations.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALMEIDA VICENTE, ANNA LUIZA SILVA; NOVOLOACA, ALEXEI; CAHAIS, VINCENT; AWADA, ZAINAB; CUENIN, CYRILLE; SPITZ, NATALIA; CARVALHO, ANDRE LOPES; EVANGELISTA, ADRIANE FEIJO; CROVADOR, CAMILA SOUZA; REIS, RUI MANUEL; et al. Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure. NATURE COMMUNICATIONS, v. 13, n. 1, p. 15-pg., . (16/15941-3, 17/09612-0)
SILVA ALMEIDA VICENTEL, ANNA LUIZA; BIANCHINI, RAQUEL ALVES; LAUS, ANA CAROLINA; MACEDO, GRAZIELA; REIS, RUI MANUEL; VAZQUEZ, VINICIUS DE LIMA. Comparison of protocols for removal of melanin from genomic DNA to optimize PCR amplification of DNA purified from highly pigmented lesions. HISTOLOGY AND HISTOPATHOLOGY, v. 34, n. 9, p. 1089-1096, . (17/09612-0, 12/04194-1, 16/15941-3)

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