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Association between inflammation and use of cannabis (Cannabis sativa) in patients in first psychotic episode

Grant number: 17/13353-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2017
Effective date (End): June 30, 2019
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal researcher:Paulo Louzada Junior
Grantee:Leonardo Marques
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/08216-2 - CRID - Center for Research in Inflammatory Diseases, AP.CEPID

Abstract

Schizophrenia and other psychotic disorders are considered severe health problems, which affect millions of people around the world, especially those at the end of adolescence or at early adulthood. Recent studies have demonstrated an inflammatory profile for these diseases, suggesting a possible inflammatory imbalance in their neurobiology. In this context, the synthesis and secretion of peripheral and central cytokines could be associated with neural functioning alterations and, thus, with the genesis of psychiatric disorders. However, the establishment of this inflammatory imbalanced phenotype may be related to the effects of several risk factors acting during critical phases of neurodevelopment, such as Cannabis sativa use. Epidemiologic studies suggest a strong association between this drug use and an increased in psychosis susceptibility, although the determination of a consistent causality could be problematic, due to the presence of several confounders, such as heterogeneous diagnosis of patients with schizophrenia and other psychotic disorders, genetic factors and duration of disease. Therefore, this study will investigate the triangulation between First Episode Psychosis, cannabis, inflammatory profile while partially controlling the confounders, aiming identify more accurately the magnitude of the effects of cannabis use on the neurobiology of schizophrenia and other psychotic disorders. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
El perfil inflamatorio puede influir en el efecto de la marihuana y en el riesgo de desarrollar psicosis 
Inflammatory profile can influence the effects of cannabis use and the risk of suffering from psychosis 
Articles published in other media outlets (27 total):
More itemsLess items
Al Día (Cuba): El perfil inflamatorio puede influir en el efecto de la marihuana y en el riesgo de desarrollar psicosis (06/Jul/2021)
Rocha al dia (Uruguai): El perfil inflamatorio puede influir en el efecto de la marihuana y en el riesgo de desarrollar psicosis (06/Jul/2021)
Infomed - Portal de la Red de Salud de Cuba (Cuba, Mayabeque): El perfil inflamatorio puede influir en el efecto de la marihuana y en el riesgo de desarrollar psicosis (05/Jul/2021)
MedMinded (Canadá): Immune system dysfunction and cannabis use linked to psychosis (22/Jun/2021)
420 Intel (Canadá): Immune system dysfunction and cannabis use linked to psychosis (22/Jun/2021)
Health Europa (Reino Unido): Immune system dysfunction and cannabis use linked to psychosis (18/Jun/2021)
Agenparl (Itália): Immune system dysfunction can modify the association between cannabis use and psychosis (17/Jun/2021)
Mirage News (Austrália): Immune system dysfunction can modify association between cannabis use and psychosis (17/Jun/2021)
La Revue Gauche: Immune system dysfunction can modify the association between cannabis use and psychosis (17/Jun/2021)
Globe Health News: Immune system dysfunction can alter the link between cannabis use and psychosis (17/Jun/2021)
Florida News Times (EUA): Immune system dysfunction can alter the association between cannabis use and psychosis (17/Jun/2021)
MediExpose (ìndia): Immune system dysfunction can modify the association between cannabis use and psychosis (17/Jun/2021)
4State News: Immune system dysfunction can modify the association between cannabis use and psychosis (17/Jun/2021)
Newspostwall (EUA): Immune system dysfunction can modify the association between cannabis use and psychosis (17/Jun/2021)
News Medical (Austrália): Immune system dysfunction can alter the link between cannabis use and psychosis (16/Jun/2021)
Medical Xpress (Reino Unido): Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Science Codex: Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Scienmag Science Magazine (Reino Unido): Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Hale Plus Hearty (Nigéria): Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Technology Alpha: Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Science News Net: Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Ground Rush Air Sports: Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Burada Biliyorum (Turquia): Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
The Health News Express: Immune system dysfunction can modify the affiliation between hashish use and psychosis (16/Jun/2021)
Dr. About: Immune system dysfunction can modify the association between cannabis use and psychosis (16/Jun/2021)
Therapeutic Solutions International, Inc. (EUA): Immune system dysfunction can alter the link between cannabis use and psychosis (16/Jun/2021)
InvestorsHub (EUA): Immune system dysfunction can alter the link between cannabis use and psychosis (16/Jun/2021)