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Effects of the phytotherapic Polypodium leucotomos on skin cancer: a preliminary investigation on human cell lines

Grant number: 16/21347-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2017
Effective date (End): June 30, 2018
Field of knowledge:Health Sciences - Medicine
Principal researcher:Nilva de Karla Cervigne
Grantee:Mariana Ayaka Yamashita
Home Institution: Faculdade de Medicina de Jundiaí (FMJ). Prefeitura Municipal de Jundiaí. Jundiaí , SP, Brazil


Skin cancer is a disease with high incidence worldwide. Because Brazil is mostly a tropical country, skin cancer has become one of the most prevalent due to the frequent exposure to the sun's ultraviolet radiation (UVR). Recently, Polypodium leucotomos (PL) extract has been used to treat inflammatory disorders and other skin diseases such as vitiligo and skin damage caused by UVR. PL seens to have photoprotective, antioxidant, and immunomodulating properties. It is speculated that it may, as well, have an antitumor action, since it could protect cellular DNA from damage caused by UVR. In the present study, we access the modulation of the proliferative, the migration and invasion processes of skin cancer cells through the administration of PL extract to determine whether this compound would show any antitumor effect on this cancer cell lines. The results obtained from our study could translate into long-term prevention of photoaging and photocarcinogenesis, and enlighten the administration of P. leucotomos as a potential beneficial tool on skin health, cancer prevention or adjuvant therapy. (AU)