Evaluation of genetic markers and quality of life in women with ovarian carcinoma

• Grant number: 16/22335-2
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): August 01, 2017
• Effective date (End): September 20, 2020
• Field of knowledge: Health Sciences - Pharmacy
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Amanda Canato Ferracini
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 18/00070-2 - Understanding EPHA5 signaling in the effects of paclitaxel-induced peripheral neuropathy on human-induced pluripotent stem cell derived sensory neurons, BE.EP.DR

Abstract

Ovarian cancer is the fifth death cause regarding malignant neoplasms in women. Thereby, in recent years, efforts have been made to demonstrate that inherited genetic markers in women with ovarian carcinoma, such as polymorphisms, may predict the response, resistance and toxicity to chemotherapy with platinum derivatives and paclitaxel, and survival. Furthermore, in ovarian carcinoma, surgery and chemotherapy can affect the quality of life. This project aims to evaluate 1) the association between inherited genetic markers in women with ovarian carcinoma with chemotherapy response and adverse reactions with carboplatin and paclitaxel, progression-free survival, overall survival; 2) and new cases evaluate the relationship between variables already cited and quality of life. This project is an observational cohort study. The study will include women, who will receive carboplatin and paclitaxel as treatment of disease, in the Women's Hospital (CAISM) at State of University of Campinas (UNICAMP). For the purpose of 1) 136 women with ovarian carcinoma and her biological material will be included by signing the Informed Consent and Informed of the Biobank of Comprehensive Care Center for Women's Health (CAISM-UNICAMP) (CONEP B -056). Genetic markers corresponding to detoxification, DNA repair, apoptosis related cell and angiogenesis polymorphisms, will be analyzed by PCR and enzymatic digestion or real time PCR in DNA extracted from peripheral blood. All adverse reactions and toxicities detected will be documented and classified according to their severity. For the purpose 2) will be applied a questionnaire of quality of life in women with ovarian carcinoma attended as new cases and begin chemotherapy with carboplatin and paclitaxel. The questionnaire will be administered before chemotherapy, in the fourth and sixth cycle. Quality of life questionnaire will be applied in women with ovarian carcinoma classified as new cases in the begin of treatment with carboplatin and paclitaxel. Questionnaire application will be repeated in the fourth, sixth cycle of chemotherapy and one year after the end of chemotherapy. Demographic and clinical data of the study participants will be obtained from the medical records. The data acquired and recorded in the collection form will be transferred to Microsoft Excel spreadsheet. The data will be analyzed using the statistical package R. The significance level will be 5%. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERRACINI, AMANDA CANATO; PEREIRA, GABRIELA; DE SOUZA, CINTHIA MADEIRA; DOS SANTOS, THIAGO FORTES CABELLO; SARIAN, LUIS OTAVIO; DERCHAIN, SOPHIE; MAZZOLA, PRISCILA GAVA. Physical and functional well-being and symptoms of ovarian cancer in women undergoing first-line of chemotherapy: a one-year follow-up. SUPPORTIVE CARE IN CANCER, JUN 2021. (19/24093-4, 16/22335-2, 18/00070-2)

FERRACINI, AMANDA CANATO; LOPES-AGUIAR, LEISA; LOURENCO, GUSTAVO JACOB; YOSHIDA, ADRIANA; LIMA, CARMEN SILVA PASSOS; SARIAN, LUIS OTAVIO; DERCHAIN, SOPHIE; KROETZ, DEANNA L.; MAZZOLA, PRISCILA GAVA. GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer. CTS-CLINICAL AND TRANSLATIONAL SCIENCE, v. 14, n. 2, DEC 2020. (16/22335-2, 18/00070-2)

FERRACINI, AMANDA CANATO; LOPES-AGUIAR, LEISA; LOURENCO, GUSTAVO JACOB; YOSHIDA, ADRIANA; LIMA, CARMEN SILVA PASSOS; SARIAN, LUIS OTAVIO; DERCHAIN, SOPHIE; KROETZ, DEANNA L.; MAZZOLA, PRISCILA GAVA. GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer. CTS-CLINICAL AND TRANSLATIONAL SCIENCE, v. 14, n. 2, p. 9-pg., 2020-12-16. (18/00070-2, 16/22335-2)

PEREIRA, GABRIELA; SURITA, FERNANDA GARANHANI; FERRACINI, AMANDA CANATO; MADEIRA, CINTHIA DE SOUZA; OLIVEIRA, LETICIA SILVA; MAZZOLA, PRISCILA GAVA. Self-Medication Among Pregnant Women: Prevalence and Associated Factors. FRONTIERS IN PHARMACOLOGY, v. 12, SEP 6 2021. (18/00070-2, 16/22335-2)

FERRACINI, AMANDA CANATO; PEREIRA, GABRIELA; DE SOUZA, CINTHIA MADEIRA; DOS SANTOS, THIAGO FORTES CABELLO; SARIAN, LUIS OTAVIO; DERCHAIN, SOPHIE; MAZZOLA, PRISCILA GAVA. Physical and functional well-being and symptoms of ovarian cancer in women undergoing first-line of chemotherapy: a one-year follow-up. SUPPORTIVE CARE IN CANCER, v. 29, n. 12, p. 7421-7430, DEC 2021. (16/22335-2, 19/24093-4, 18/00070-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FERRACINI, Amanda Canato. Evaluation of genetic polymorphisms and quality of life in women with ovarian carcinoma. 2021. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.