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Epigenetic markers related to appetite/satiety in women with grade III obesity before and after a Roux-en-Y gastric bypass

Grant number: 17/05927-6
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2017
Effective date (End): July 31, 2019
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Carla Barbosa Nonino
Grantee:Leticia Santana Wolf
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Introduction: The indication of bariatric surgery has been growing in the past years due to its success in weight loss and improvement in metabolic, disorders such as diabetes and dyslipidemias. However, recent studies show that genetic variants may explain the predisposition to obesity, which is related to a resistance to weight loss after a surgical intervention. In addition, there is evidence that genetics contributes substantially to the regulation of body weight, through a complex interaction between hormones and neuropeptides, under the main control of hypothalamic nuclei. In this context, genes related to appetite / satiety play an important role in the regulation of metabolism and may be associated with weight control. Objective: To evaluate non-methylation pattern modifications of genes related to the appetite / satiety pathway in women with severe obesity before and after gastric bypass Roux-Y (DGYR). Casuistry and Methodology: Twenty female subjects, aged 18 to 60 years old, will be selected, divided into 2 groups: 1. Surgical Intervention Group, composed of 10 women with severe obesity BMI > 40 kg / m²) and 2. Control group, composed of 10 women in eutrophy (BMI between 18.5 and 24.9 kg / m²) without associated comorbidities. It is a longitudinal study, dietary, anthropometric, biochemical and genetic analysis have been performed to evaluate the methylation of the genes related to the appetite / satiety pathway before and after six months of DGYR. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
WOLF, Leticia Santana. Epigenetic markers related to the apettite/satiety pathway in obese women before and after Roux en Y gastric bypass. 2020. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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