Characterization of calcium aluminate cement-based compositions for application in the repair and regeneration of bone tissue

• Grant number: 17/03218-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): July 01, 2017
• Effective date (End): November 30, 2018
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Ivone Regina de Oliveira
• Grantee: Gabriela Do Vale Vieira
• Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil

Abstract

Ca-aluminate as a biomaterial has been evaluated for over two decades with regard to general physical, mechanical, and biocompatible properties. Due to its unique curing/hardening characteristics and related microstructure, Ca-aluminate based materials exhibit a great potential in the biomaterial field. An overview of the use of Ca-aluminate as a biomaterial in odontology and orthopaedics was already published. Aluminate cements are used as dental restorative materials and in orthopedics for repairing bone flaws based on their composition and thermal expansion coeficient, which are very similar to that of bones and teeth. The responsible counselor for this project has contributed to these studies through the development of approved projects FAPESP (2009/17451-0; 2013/22502-8); patent granted (PI0704502-6) "aluminous cement-based composition for application in Endodontics and cementitious product obtained thereof"; and technical articles. CAC-blends containing 4 wt% of different compounds (alumina, zirconia, zinc oxide, tricalcium phosphate and hydroxyapatite) resulted in samples with similar or higher mechanical strength than PMMA. SEM results showed that precipitation of hydroxyapatite occurred on blends but not on PMMA and the CAC-ZnO-Bi2O3 (15:10 wt%) composition presented suitable values of radiopacity. Blends with collagen, zinc oxide and zirconia presented cell viability similar to control. Studies about CAC-10 wt% CaCl2 (CAC+) supported the acquisition of the osteogenic cell phenotype in vitro, rendering this novel material a potential alternative in endodontic procedures. Within this context, this project proposes to continue these studies through complementary physical and chemical testing that still are needed for evaluation as CAC-base compositions efficiency in the repair and regeneration of bone tissue compared to PMMA. (AU)