|Support type:||Scholarships in Brazil - Post-Doctorate|
|Effective date (Start):||August 01, 2017|
|Effective date (End):||December 31, 2019|
|Field of knowledge:||Health Sciences - Dentistry - Periodontology|
|Principal Investigator:||Arthur Belem Novaes Junior|
|Grantee:||Umberto Demoner Ramos|
|Home Institution:||Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil|
To date, there is no gold standard treatment for periimplantitis. Then, the establishment of an effective therapeutic protocol for decontamination and re-osseointegration is needed. The aim of this study is to evaluate the effect of antimicrobial photodynamic therapy (aPDT) associated with L-PRF in decontamination and re-osseointegration of periimplant defects. The mandibular premolars of 8 minipigs will be extracted bilaterally, preceding the insertion of 6 dental implants. After a healing period, ligatures will be placed for 2 months for induction of the experimental periimplantitis and 15 days before treatment, ligatures will be removed. Two antiinfective protocols will be used to decontaminate implant surface: mechanical treatment associated or not to L-PRF, aPDTassociated or not with L-PRF. Twelve weeks post treatment, the implants will receive healing abutment. To characterize the periimplantitis will be performed radiographic assessment of bone loss and clinical progression of the disease. Treatment effect will be evaluated by means of clinical data, analysis of the defect extension, and histomorphometry. It is expected that the implants treated with aPDT and L-PRF presents higher decontamination indexes and better re-osseointegration rates.