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Clinical caracterization of the experimental periimplantitis and evaluation of antimicrobial photodynamic therapy with or without the use of L-PRF on the treatment of induced periimplant disease.

Grant number: 17/02910-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2017
Effective date (End): December 31, 2019
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Arthur Belem Novaes Junior
Grantee:Umberto Demoner Ramos
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


To date, there is no gold standard treatment for periimplantitis. Then, the establishment of an effective therapeutic protocol for decontamination and re-osseointegration is needed. The aim of this study is to evaluate the effect of antimicrobial photodynamic therapy (aPDT) associated with L-PRF in decontamination and re-osseointegration of periimplant defects. The mandibular premolars of 8 minipigs will be extracted bilaterally, preceding the insertion of 6 dental implants. After a healing period, ligatures will be placed for 2 months for induction of the experimental periimplantitis and 15 days before treatment, ligatures will be removed. Two antiinfective protocols will be used to decontaminate implant surface: mechanical treatment associated or not to L-PRF, aPDTassociated or not with L-PRF. Twelve weeks post treatment, the implants will receive healing abutment. To characterize the periimplantitis will be performed radiographic assessment of bone loss and clinical progression of the disease. Treatment effect will be evaluated by means of clinical data, analysis of the defect extension, and histomorphometry. It is expected that the implants treated with aPDT and L-PRF presents higher decontamination indexes and better re-osseointegration rates.