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Effectiveness and safety of products containing repellents sold in Brazil against the bite of Aedes aegypti and Aedes albopictus

Grant number: 17/07813-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2017
Effective date (End): January 31, 2019
Field of knowledge:Health Sciences - Collective Health - Public Health
Principal Investigator:Cristiane de Cássia Bergamaschi
Grantee:Maria Raquel Gomes Fernandes
Home Institution: Pró-Reitoria Acadêmica. Universidade de Sorocaba (UNISO). Sorocaba , SP, Brazil


Dengue, zika and chikungunya affect mainly the population of tropical countries and cause important problems for public health. Prevention is the most effective way to fight these diseases and depends mainly on the control of the vector mosquitoes and on personal protection by the use of repellants. There is no evidence available about the effectiveness and safety of repellents sold in Brazil. Objectives: To evaluate the effectiveness and safety of products containing repellents sold in Brazil against the bite of Aedes aegypti and Aedes albopictus. Methods: It will be developed a systematic review of randomized and nonrandomized studies comparing products containing repellents registered in the National Health Surveillance Agency (Agência Nacional de Vigilância Sanitária - ANVISA) in comparison with the control group (placebo or active control). Using terms that include all repellents sold in Brazil: DEET, icaridine, IR3535; and natural products (Cymbopogon nardus, Carapa guianensis and Eucalyptus globulus) the following databases will be searched: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, Web of Science, Health Star, AMED, LILACS, CAB abstracts,, clinical trial records of WHO and CAPES national bank of thesis; without language or publication date restriction. Outcomes of interest include: incidence of infection by virus Zika, Dengue or Chikungunya; frequency of adverse events (AEs) and serious AE; average protection time against the bite; protection time e 95%; percentage of repellency and effective minimum dose. A team of reviewers will evaluate each study independently and in pairs. For eligible studies, the same reviewers will perform data extraction and bias risk assessment. Expected results: The results of this study may provide new information about the effectiveness and safety in the use of repellents for diseases that epidemiologically pose big problems for public health in many countries. Evaluating repellents based on Brazilian medicinal plants sold in Brazil can also validate the use of such products and contribute to greater knowledge of Brazilian natural resources against these vectors. This study may also identify key areas for future research. (AU)