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The effects of diabetes on the growth plate of both healthy and diabetic rats

Grant number: 16/19692-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2017
Effective date (End): July 31, 2018
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Ariane Zamarioli
Grantee:Beatriz Paganini Trani
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Diabetes mellitus (DM) is a disease that greatly affects the quality of cartilage tissue and thus, the growth plate. Purpose: to determine the effects of DM on the quality of growth plate in diabetic rats and verify the effects of vibration therapy on the growth plate of healthy and diabetic rats. Materials and Methods: 80 rats will be divided into 4 groups (n=20/group): (1) CON: healthy rats; (2) CON+TV: healthy rats submitted to vibration therapy; (3) DM: diabetic rats; (4) DM+TV: diabetic rats submitted to vibration therapy. Each group will be divided into 2 subgroups according to the follow-up period: 44 and 58 days after induction of diabetes. Diabetes will be induced by a single intravenous application of 40 mg/kg streptozotocin. In control animals groups the application of citrate solution will be performed with same dose and procedure. After a week, the animals will be diagnosed as diabetic if the glycemic rate exceeds 250 mg/dl and this procedure will be continued once a week. After 30 days of induction DM/placebo the animals of groups CON+TV and DM+TV will be submitted to vibration therapy 3d/wk, for 20 minutes, at 14 and 28 days period (according with the subgroups). Growth plate will be assessed by: macroscopic analysis; optical microscopy and ¼CT. These results will provide knowledge about changes in the growth plate of diabetic animals and the effects of vibration therapy on the quality of this tissue in healthy and diabetic rats. (AU)

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