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Contribution to integrated studies for leaf-cutting ants control: search for new insecticides and fungicides - nanoencapsulation

Grant number: 17/15455-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2017
Effective date (End): December 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:João Batista Fernandes
Grantee:Hugo César Ramos de Jesus
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:12/25299-6 - Integrated studies for leaf cutting control, AP.TEM
Associated scholarship(s):18/21746-4 - Study of proteases and their substrates from Atta sexdens using degradomics approaches, BE.EP.PD


The predatory power of leaf-cutting ants and their power to transform the soil have been known for centuries. The use of plants for the control of ants is known to farmers and can be better explored using chemosystematic knowledge of plants. Obtaining natural products from plants or microorganisms with potential insecticidal or fungicidal action on the nest of leaf-cutting ants, as well as synthetic analogues and modes of applications and actions, and their determinations are the general objectives of the project. The participation in the execution of the project, as a post doctor, aims to contribute to its development, counting with the contribution of doctors with experiences that can broaden the intended results and mainly complete the training of candidates for scholarships.The candidate for the scholarship, Dr. Hugo César Ramos de Jesus, will focus on the microorganisms involved in the fungal mass of Atta sexdens rubropilosa and new plants of the Sapindales order for large-scale production of natural products with insecticidal activity, and/or fungicide, and/or on enzymes of the nest of leaf-cutting ants; to study the biosynthesis of active compounds; to obtain new complexes with metals to increase the insecticidal or fungicidal activity of natural metals products (Metalo-insecticides luminescent intelligent); to know the mechanisms of action and their active sites; to evaluate the aquatic toxicity on the fish "paulistinha" (Brachdanio rerio) and acute on the luminescent bacterium Vibrio fischeri, in the enzymes in studies; and to realize microencapsulations of the active compounds.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, TAYNARA L.; DOS SANTOS, DEBORAH A.; DE JESUS, HUGO C. R.; BROMME, DIETER; FERNANDES, JOAO B.; PAIXAO, MARCIO W.; CORREA, ARLENE G.; VIEIRA, PAULO C. Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors. Bioorganic & Medicinal Chemistry, v. 28, n. 15 AUG 1 2020. Web of Science Citations: 0.
SILVA, TAYNARA L.; BARTOLOMEU, ALOISIO DE A.; DE JESUS, HUGO C. R.; DE OLIVEIRA, KLEBER T.; FERNANDES, JOAO B.; BROMME, DIETER; VIEIRA, PAULO C. New Synthetic Quinolines as Cathepsin K Inhibitors. Journal of the Brazilian Chemical Society, v. 31, n. 8, p. 1605-1613, AUG 2020. Web of Science Citations: 0.
MARCHI, RAFAEL C.; SILVA, ELDEVAN S.; SANTOS, JOSENILTON J.; GUILOSKI, IZONETE C.; DE JESUS, HUGO CESAR R.; DE AGUIAR, INARA; KOCK, FLAVIO V. C.; VENANCIO, TIAGO; DA SILVA, MARIA FATIMA G. F.; FERNANDES, JOAO BATISTA; VITAL, MARIA A. B. F.; SOUZA, LEONARDO CASTRO; SILVA DE ASSIS, HELENA C.; SKIBSTED, LEIF H.; CARLOS, ROSE M. Synthesis, Characterization, and Low-Toxicity Study of a Magnesium(II) Complex Containing an Isovanillate Group. ACS OMEGA, v. 5, n. 7, p. 3504-3512, FEB 25 2020. Web of Science Citations: 0.

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