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Obesity and insulin resistance prevention through aerobic physical training: role of the renin angiotensin system on white adipose tissue

Grant number: 16/23783-9
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2017
Effective date (End): March 31, 2019
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal researcher:Fabiana de Sant'Anna Evangelista
Grantee:Anna Laura Viacava Américo
Home Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Obesity has become one of the most important public health problems, it is a risk factor for the development of insulin resistance, Type 2 Diabetes (DM2) and cardiovascular diseases, and is considered one of the five leading causes of death worldwide. The understanding of the cellular mechanisms of Metabolic Diseases (MD) enables to identify new therapeutic targets, and in this context, the investigation of the role of the Renin Angiotensin System (RAS), specifically the ACE/Ang II/AT1 axis and ACE2/Ang (1-7)/MAS looks promising. While hyperactivity ACE/Ang II/AT1 axis exerts broad deleterious effect on energy metabolism, induces obesity, insulin resistance in peripheral tissues and DM2, the activation of the ACE2/Ang (1-7)/MAS axis acts on opposite direction, being able to attenuate the clinical manifestations of DM. Aerobic Exercise Training (AET) has been widely recommended for the prevention and treatment of DM to induce adaptations in metabolically active tissues reflecting in the improvement of the oxidative capacity, reducing lipid deposits, improves the balance of pro and anti-cytokines inflammatory and increasing insulin sensitivity. Recently, the association of AET with the differentiation of brown adipocytes (Beige) in white adipose tissue (WAT; browning of WAT) and consequent increase in the thermogenic potential, increased the relevance of the WAT in controlling energy balance and prevention of DM. Whereas a portion of the beneficial responses AET may be mediated by the reduction of ACE/Ang II/AT1 axis and/or increasing ACE2/Ang (1-7)/MAS axis, the aim of the present project is to study the effect of AET on the axis of RAS in the WAT and the repercussions for two possible mechanisms by which the RAS may be involved in the prevention of obesity and insulin resistance: the browning of the WAT and WAT inflammatory response. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AMERICO, ANNA LAURA V.; MULLER, CYNTHIA R.; VECCHIATTO, BRUNO; MARTUCCI, LUIZ FELIPE; FONSECA-ALANIZ, MIRIAM H.; EVANGELISTA, FABIANA S.. Aerobic exercise training prevents obesity and insulin resistance independent of the renin angiotensin system modulation in the subcutaneous white adipose tissue. PLoS One, v. 14, n. 4, . (15/04948-4, 16/23783-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
AMÉRICO, Anna Laura Viacava. Prevention of obesity and insulin resistance through aerobic physical training: role of the renin angiotensin system in white adipose tissue. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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