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45S5 bioglass scaffolds to repare damages in bone tissue

Grant number: 17/12932-6
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2017
Effective date (End): August 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Celso Aparecido Bertran
Grantee:Mariana de Oliveira Silva
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release, AP.TEM

Abstract

The 45S5 bioglass® is one the most promising materials to be used in bone tissue damages, especially due to its biocompatibility, bioactivity and osteoinduction. However, the production of BG 45S5 scaffolds with a good compromise between porosity and mechanical properties results in crystallization of the glass because of its small sintering window, lowering the properties that make it such an interesting material. This project proposes an alternative to produce a 45S5 scaffold using particles of this glass made by melt and quenching together with the "Fritas" method. The bioglass particles will be bound by a BG45S5 bioglass film produced by sol-gel and surfactant and hydrogen peroxide to produce pores (gel foaming technique). Bioglass films produced by sol-gel transform into bioglass without crystallization at temperatures lower than the Tg. The characterization of the final material with microscopy, mechanical tests, leaching profile and in vitro and in vivo tests will allow evaluating the scaffold, especially its biological response.