Whole-body vibration evaluation on cutaneous wound healing of rats

• Grant number: 17/14098-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2017
• End date: August 31, 2018
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Sheila Canevese Rahal
• Grantee: Frederico Matheus Ducatti de Gois
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Protocols for treatment of cutaneous wounds have as main objective to improve the efficiency of the cicatrization and different equipments are used for this purpose. The present work aims to evaluate and analyze the healing properties of whole-body vibration, surgically induced, in cutaneous wound of rats. It will be used 54 healthy adult males Wistar rats. They will be allocated, randomly, in three groups of 18 animals: Group 1 - negative control - rats with wounds submitted to treatment with saline solution (0.9%), without the action of vibratory platform; Group 2 - positive control - rats with wounds submitted to treatment with healing ointment, without the action of vibratory platform; Group 3 - rats with wounds submitted to the action of the vibratory platform. Six animals from each group will undergo excisional biopsies after euthanasia at three different moments: seventh day after start the treatment, 14th day and 21st day after the start the treatment. Macroscopic, histological and magnetic resonance evaluations of the wounds will be performed. Statistical analysis will be used for analysis of variance (ANOVA) for repeated samples, with contrasts by Tukey test and Kolmogorov-Smirnov test. Data that do not assemble the normality characteristics will be used Friedman test. For comparison between the four groups of the study, analysis of variance for independent samples (ANOVA One way) for normal data, and Kruskal-Wallis test, for data outside the normality conditions will be used. Differences will be considered significant with p  0.05. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AVILA DIAS MACIEL, DIANA MILANEZ; RAHAL, SHEILA CANEVESE; CHARAS DOS SANTOS, IVAN FELISMINO; FONSECA ALVES, CARLOS EDUARDO; DE ABREU SAMPAIO, ALEXANDRE BOTEIHO; NAGAI, LAIS ROSA; DUARTE FERRAZ DE CAMARGO, BARBARA WAGNER; SALEWSKI, GABRIELLA CUNHA. Healing of Skin Wounds in Rats: Influence of Low-Level Laser Therapy, Alone or Combined with Natural Products. Acta Scientiae Veterinariae, v. 48, p. 10-pg., 2020-05-07. (17/14098-3)

AVILA DIAS MACIEL, DIANA MILANEZ; RAHAL, SHEILA CANEVESE; CHARAS DOS SANTOS, IVAN FELISMINO; FONSECA ALVES, CARLOS EDUARDO; DE ABREU SAMPAIO, ALEXANDRE BOTEIHO; NAGAI, LAIS ROSA; DUARTE FERRAZ DE CAMARGO, BARBARA WAGNER; SALEWSKI, GABRIELLA CUNHA. . Acta Scientiae Veterinariae, v. 48, MAY 7 2020. (17/14098-3)

VIEIRA ROSSETTO, VICTOR JOSE; FERRANTI, CAMILA CREPALDI; FIRMO, BRUNA FERNANDA; MIAZAKI, DANIELA ADACHI; DOS SANTOS, DANIELA CARVALHO; SEQUEIRA, JULIO LOPES; SEULLNER BRANDAO, CLAUDIA VALERIA. Digital Measurement of the Diameter of the Collagen Fibers by Transmission Electron Microscopy for Diagnosis of Ehlers-Danlos Syndrome-Like in Small Animals. Acta Scientiae Veterinariae, v. 49, n. 1, 2021. (17/14098-3)