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Pluronic F127 thermosensitive hydrogels functionalized with terminal groups releasing nitric oxide

Grant number: 17/19253-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2017
Effective date (End): January 14, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal researcher:Marcelo Ganzarolli de Oliveira
Grantee:Guilherme Fadel Picheth
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release, AP.TEM

Abstract

The main objective of this project is the development of new F127 hydrogels functionalized with terminal S-nitrosothiol (SNO) groups. The modified F127 (F127-SNO) hydrogels are expected to retain their thermo-sensitive property, undergoing gelation with the increase in temperature and to be capable of releasing NO thermally and photochemically. The first step in this development will be the chemical modification of F127 based on its reaction with 3,3-dithiodipropionil chloride in the presence of triethylamine, to yield F127-SS. The next reaction steps will be the reduction of F127-SS with D,L-dithiothreitol (DTT) to yield thiol end-caped F127 (F127SH) and the S-nitrosation reaction of the F127SH solutions using a N2O3-based nitrosation system. The kinetics of NO release from F127SNO will be monitored in real time by chemiluminescence. Micellization and gelation processes will be investigated using High Sensitivity Differential Scanning Calorimetry (HSDSC) and in situ SAXS measurements carried out at the SAXS1 beamline of the Brazilian synchrotron source, LNLS, Campinas, Brazil. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHAMPEAU, MATHILDE; POVOA, VALERIA; MILITAO, LUCAS; CABRINI, FLAVIA M.; PICHETH, GUILHERME F.; MENEAU, FLORIAN; JARA, CARLOS P.; DE ARAUJO, ELIANA P.; DE OLIVEIRA, MARCELO G.. Supramolecular poly(acrylic acid)/F127 hydrogel with hydration-controlled nitric oxide release for enhancing wound healing. Acta Biomaterialia, v. 74, p. 312-325, . (14/24955-2, 13/07607-8, 17/19253-7, 15/17515-9, 16/02414-5)
PICHETH, GUILHERME F.; MARINI, THATIANE C.; TALADRIZ-BLANCO, PATRICIA; SHIMAMOTO, GUSTAVO G.; DOS SANTOS, GIOVANNA J. V. P.; MENEAU, FLORIAN; DE OLIVEIRA, MARCELO G.. Influence of Pluronic F127 microenvironments on the photochemical nitric oxide release from S-nitrosoglutathione. Journal of Colloid and Interface Science, v. 544, p. 217-229, . (13/07173-8, 17/04615-0, 14/03266-4, 17/19253-7, 16/02414-5)
DE SOUZA, GABRIELA FREITAS P.; DENADAI, JAQUELINE PRISCILLA; PICHETH, GUILHERME F.; DE OLIVEIRA, MARCELO GANZAROLLI. Long-term decomposition of aqueous S-nitrosoglutathione and S-nitroso-N-acetylcysteine: Influence of concentration, temperature, pH and light. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 84, p. 30-37, . (17/19253-7, 16/02414-5)
GIGLIO, LEONARDO P.; PICHETH, GUILHERME F.; LOVSCHALL, KAJA BORUP; ZELIKIN, ALEXANDER N.; DE OLIVEIRA, MARCELO G.. S-nitrosothiol-terminated poly(vinyl alcohol): Nitric oxide release and skin blood flow response. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 98, p. 41-49, . (17/04622-7, 16/02414-5, 17/19253-7)
PICHETH, GUILHERME F.; DA SILVA, LAURA C. E.; GIGLIO, LEONARDO P.; PLIVELIC, TOMAS S.; DE OLIVEIRA, MARCELO G.. S-nitrosothiol-terminated Pluronic F127: Influence of microstructure on nitric oxide release. Journal of Colloid and Interface Science, v. 576, p. 457-467, . (18/14142-5, 17/04622-7, 16/02414-5, 17/19253-7)
POVOA, VALERIA C. O.; DOS SANTOS, GIOVANNA J. V. P.; PICHETH, GUILHERME F.; JARA, CARLOS P.; DA SILVA, LAURA C. E.; DE ARAUJO, ELIANA P.; DE OLIVEIRA, MARCELO G.. Wound healing action of nitric oxide-releasing self-expandable collagen sponge. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v. 14, n. 6, . (13/07607-8, 18/14142-5, 17/04615-0, 16/02414-5, 17/19253-7)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.