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The role of mast cells upon the in vitro osteogenic differentiation of the mesenchymal stromal cells from the bone marrow of mice

Grant number: 17/07095-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2017
Effective date (End): September 30, 2019
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Sandra Helena Penha de Oliveira
Grantee:Maria Carolina Linjardi de Sousa
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
Associated research grant:15/03965-2 - Role of the renin-angiotensin system in different oral inflammatory models: an experimental interdisciplinary and clinical approach, AP.TEM


Bone tissue is formed by some important cell types, such as: osteoblasts, osteoclasts and osteocytes. Osteoblasts are bone-forming cells, which synthesize and secrete collagen fibers and other organic components necessary for the formation of extracellular bone matrix, in particular collagen I, bone sialoprotein, osteocalcin and osteopontin. The osteogenesis process is divided into three stages (proliferation, phenotypic impairment, and matrix synthesis). It involves many factors for an ostoprogenitor cell to differentiate as the involvement of growth factors, cytokines and chemokines. Many of these factors may come from the resident cells themselves located near the bone tissue that contribute, or not, to the progenitor cells to assume specific phenotypes. Studies have revealed the possibility that mast cells have the ability to regulate bone turnover through their preformed products since these cells are strategically located around the periosteal surface, thus being in close anatomical proximity to periosteal osteoblasts. Thus, understanding the role of mast cells in the osteoblast differentiation of osteoblasts, as well as the mechanisms involved in this process, is of extreme importance in order to better understand the participation of these cells as well as their mediators in the development of bone disorders for example, in the osteoporosis. Thus, in the present study, we propose to evaluate the role of mast cells on the osteoblastic differentiation of mesenchymal stromal cells from the bone marrow of mice in order to investigate possible mechanisms involved in this process.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BALERA BRITO, VICTOR GUSTAVO; PATROCINIO, MARIANA SOUSA; LINJARDI SOUSA, MARIA CAROLINA; ALVES BARRETO, AYNA EMANUELLI; TFAILE FRASNELLI, SABRINA CRUZ; LARA, VANESSA SOARES; SANTOS, CARLOS FERREIRA; PENHA OLIVEIRA, SANDRA HELENA. Mast cells contribute to alveolar bone loss in Spontaneously Hypertensive Rats with periodontal disease regulating cytokines production. PLoS One, v. 16, n. 3, . (18/23676-3, 17/05873-3, 17/07095-8, 17/02271-2, 15/03965-2)
BRITO, VICTOR GUSTAVO BALERA; PATROCINIO, MARIANA SOUSA; DE SOUSA, MARIA CAROLINA LINJARDI; BARRETO, AYNA EMANUELLI ALVES; FRASNELLI, SABRINA CRUZ TFAILE; LARA, VANESSA SOARES; SANTOS, CARLOS FERREIRA; OLIVEIRA, SANDRA HELENA PENHA. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. FRONTIERS IN PHARMACOLOGY, v. 11, . (17/02271-2, 18/23676-3, 17/05873-3, 17/07095-8, 15/03965-2)

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