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Evaluation of the BAT paramyxoviruses in Brazil: molecular characterization, evolutionary analyses and risk assessment of distinct paramyxovirus lineages

Grant number: 17/20744-5
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): November 01, 2017
Effective date (End): October 31, 2018
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Edison Luiz Durigon
Grantee:Angélica Cristine Góes de Almeida Campos
Supervisor abroad: Jan Felix Drexler
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Charité - Universitätsmedizin Berlin, Germany  
Associated to the scholarship:14/15090-8 - Monitoring of influenza virus in bats from tropical and sub tropical region of Brazil, BP.PD

Abstract

In the last decades some viruses has been concern among researchers and health professionalsbecause they can emerge silently or aggressively. Generally the emerging infectious diseasesare originated by the virus transmission from wildlife or domestic animals to humans(zoonosis). Generally emerging viruses are caused by new or unknown agents and they canbe responsible by epidemics outbreaks. Every year million of people are infected by flu andhistorically Influenza virus are responsible by seasonal pandemics and epidemics outbreaks.The prevention and emerging infection control request the identification of the pathogensand the transmission process by the way that virus can cross species barrier. The livestockintense has been identified as one important factor to the emergence of wildlife and domesticanimals pathogens in human population. Carnivora and Chiroptera orders are recognized aswild reservoirs for rabies virus and have been described as source of multiple pathogenicviruses as lyssavirus, coronavirus, filovirus, henipavirus and paramyxovirus to domesticanimals and humans. Two new influenza viruses, H17N10 and H18N11, were recentlydescribed and isolated in American bats. Despite the divergence from other known InfluenzaA viruses, these data shown that despite the viral divergence the Influenza A virus, the flubat viruses has match with genetic material changes in human cells with human Influenzavirus, suggesting a potential capability for reassortment and contributions to new Influenzapandemic or panzootic. The early prevention, detection, characterization and the understandsof the genetic variability of bat flu is a urgent need to better analysis of the risk ofreassortment with flu from other animal hosts being essential to protect public health. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALMEIDA CAMPOS, ANGELICA CRISTINE; BENTIM GOES, LUIZ GUSTAVO; MOREIRA-SOTO, ANDRES; DE CARVALHO, CRISTIANO; AMBAR, GUILHERME; SANDER, ANNA-LENA; FISCHER, CARLO; DA ROSA, ADRIANA RUCKERT; DE OLIVEIRA, DEBORA CARDOSO; KATAOKA, ANA PAULA G.; PEDRO, WAGNER ANDRE; MARTORELLI, LUZIA FATIMA A.; QUEIROZ, LUZIA HELENA; CRUZ-NETO, ARIOVALDO P.; DURIGON, EDISON LUIZ; DREXLER, JAN FELIX. Bat Influenza A(HL18NL11) Virus in Fruit Bats, Brazil. Emerging Infectious Diseases, v. 25, n. 2, p. 333-337, FEB 2019. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.