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Spectroscopic and magnetic characterization of metallo-pharmaceuticals immobilized in hybrid matrices for drug delivery

Grant number: 17/21919-3
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): March 01, 2018
Effective date (End): February 28, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Ana Maria da Costa Ferreira
Grantee:Eduardo Guimarães Vieira
Supervisor abroad: Floriana Tuna
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : University of Manchester, England  
Associated to the scholarship:16/16735-8 - Imobilization of potential metallopharmaceuticals in inorganic and organic matrices for modified delivery, BP.PD

Abstract

As mentioned in our previously approved project (FAPESP process: 2016/16735-8), the research internship abroad (RIA) would be requested according to the need and development of the work. In this project, we intend to investigate a number of paramagnetic metal complexes based on isatin and/or 2-imidazolecarboxaldehyde loaded on silica-based matrices. The free and loaded complexes will be studied in detail by magnetic and electron paramagnetic resonance techniques (EPR) taking advantage of the excellent research facilities and world-class infrastructure existent at the National UK EPR Facility and Service Center of the University of Manchester. Our main focus is to use advanced electron paramagnetic resonance (EPR) techniques to gain information of the coordination environment of the paramagnetic metals at first coordination sphere, and further determine their electronic structures and changes that occur in modified matrices when host-guest chemistry is used. Preliminary continuous-wave (CW) X-band EPR studies were carried out at the University of São Paulo (USP); however, additional information is needed in order to understand essential properties related to the metal coordination and electronic structures, and to quantify hyperfine interactions between metals and surrounding nuclei. Use of pulsed EPR techniques (ENDOR, ESEEM, HYSCORE, ELDOR, DEER), available at several microwave frequencies (S-, X- and Q) at the University of Manchester, will further allow to determine with accuracy the nature of the donor atoms binding to the metal centers, and the strength of electron-electron and electron-nuclei interactions. We can also investigate the spin dynamics in such complex structures by doing magnetic relaxation measurements, measure distances between spins, and quantify anisotropy parameters that relate to the structures of the complexes used. Our studies will be complemented by SQUID magnetometry measurements, and CW EPR at frequencies ranging from 1 GHz (S-band) to 94 GHz (W-band), which are not available at the University of São Paulo.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIEIRA, EDUARDO GUIMARAES; MIGUEL, RODRIGO BERNARDI; DA SILVA, DANIEL RODRIGUES; FAZZI, RODRIGO BONI; ALVES DE COUTO, RICARDO ALEXANDRE; MARIN, JAYR HENRIQUE; ARRUDA TEMPERINI, MARCIA LAUDELINA; SHINOHARA, JORGE DA SILVA; TOMA, HENRIQUE EISI; RUSSO, LILIAN CRISTINA; MAGALHAES, YULI THAMIRES; DIAS FILHO, NEWTON LUIZ; FORTI, FABIO LUIZ; DA COSTA FERREIRA, ANA MARIA. Functionalized nanoparticles as adjuvant to increase the cytotoxicity of metallodrugs toward tumor cells. NEW JOURNAL OF CHEMISTRY, v. 43, n. 1, p. 386-398, JAN 7 2019. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.