Standardization of phytomedicines for the treatment of chronic diseases

• Grant number: 16/21044-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): December 01, 2017
• Effective date (End): August 31, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Wagner Vilegas
• Grantee: Ana Caroline Zanatta Silva
• Host Institution: Instituto de Biociências (IB-CLP). Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil
• Associated scholarship(s): 19/18673-8 - Metabolomic study of Brazilian plants used in the treatment of chronic diseases, BE.EP.DR

Abstract

With increasing life expectancy, the prevalence of chronic diseases (peptic ulcers, inflammatory bowel disease, metabolic syndrome) has risen among the population. High cost and adverse side effects have led to a search for herbal medicines. However, the market is more demanding, and a search of safer and effective alternatives to prevent and cure these diseases is needed. In this context, this project linked to the thematic project "Herbal standardized for the treatment of chronic diseases" FAPESP, aims to incorporate Phytomedication plant extracts that have been studied by the group with potential anti-ulcer action and are viable for use as herbal medicines. For the project development will be necessary to assess the seasonal variability of plant species, to apply concepts of green chemistry, and further study of these new formulations in chronic diseases of the digestive tract and metabolic syndrome. For this, we need to develop and evaluate chemical, toxicological and pharmacological, preparations of some of the plant species studied in previous projects that have shown therapeutic potential associated with safe use. The studies will be conducted for species Byrsonima intermedia A. Juss. (Malpighiaceae), Serjania marginata Casar. (Sapindaceae) and Terminalia catappa L. (Combretaceae), which showed promising gastroprotective activity, anti-inflammatory and no toxicity. The species B. intermedia and S. marginata still have significant results of antimutagenicity. Promising activities and ease of collection and / or cultivation were two of the parameters that have guided us for the choice of these species.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VALERINO-DIAZ, ALEXANDER B.; ZANATTA, ANA C.; GAMIOTEA-TURRO, DAYLIN; BOLELA BOVO CANDIDO, ANA CAROLINA; MAGALHAES, LIZANDRA GUIDI; VILEGAS, WAGNER; DOS SANTOS, LOURDES CAMPANER. An enquiry into antileishmanial activity and quantitative analysis of polyhydroxylated steroidal saponins from Solanum paniculatum L. leaves. Journal of Pharmaceutical and Biomedical Analysis, v. 191, NOV 30 2020. (09/52237-9, 16/21044-4)

ZANATTA, ANA C.; VILEGAS, WAGNER; EDRADA-EBEL, RUANGELIE. UHPLC-(ESI)-HRMS and NMR-Based Metabolomics Approach to Access the Seasonality of Byrsonima intermedia and Serjania marginata From Brazilian Cerrado Flora Diversity. FRONTIERS IN CHEMISTRY, v. 9, JUL 6 2021. (16/21044-4, 19/18673-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Ana Caroline Zanatta. Multidisciplinary and multicomponent approach applied to the characterization and development of phytopreparations from Byrsonima intermedia, Serjania marginata and Terminalia catappa. 2021. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Química. Araraquara Araraquara.