With increasing life expectancy, the prevalence of chronic diseases (peptic ulcers, inflammatory bowel disease, metabolic syndrome) has risen among the population. High cost and adverse side effects have led to a search for herbal medicines. However, the market is more demanding, and a search of safer and effective alternatives to prevent and cure these diseases is needed. In this context, this project linked to the thematic project "Herbal standardized for the treatment of chronic diseases" FAPESP, aims to incorporate Phytomedication plant extracts that have been studied by the group with potential anti-ulcer action and are viable for use as herbal medicines. For the project development will be necessary to assess the seasonal variability of plant species, to apply concepts of green chemistry, and further study of these new formulations in chronic diseases of the digestive tract and metabolic syndrome. For this, we need to develop and evaluate chemical, toxicological and pharmacological, preparations of some of the plant species studied in previous projects that have shown therapeutic potential associated with safe use. The studies will be conducted for species Byrsonima intermedia A. Juss. (Malpighiaceae), Serjania marginata Casar. (Sapindaceae) and Terminalia catappa L. (Combretaceae), which showed promising gastroprotective activity, anti-inflammatory and no toxicity. The species B. intermedia and S. marginata still have significant results of antimutagenicity. Promising activities and ease of collection and / or cultivation were two of the parameters that have guided us for the choice of these species.
News published in Agência FAPESP Newsletter about the scholarship: