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Non-invasive urodynamics: study of the efficacy and safety of a new model

Grant number: 17/17745-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2017
Effective date (End): May 31, 2018
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Carlos Arturo Levi Dancona
Grantee:Marianne Yang Yu
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Prostatic hyperplasia is the main cause of lower urinary tract symptoms. Nowadays, the pressure flow study is the gold standard in the diagnosis of bladder outlet obstruction (Arnolds et al, 2009). However, such procedure is expensive, invasive and time-consuming. Not only does the patient experiment significant pain and discomfort, but is also highly susceptible to urinary infections. Due to that, new non-invasive methods have been developed to diagnose bladder outlet obstruction. The condom catheter method was the first one. In this method, the device is attached to the penis and it completely interrupts the urinary flow. This causes a hydraulic lock of the lower urinary tract, which then becomes a closed system. The pressure stables and is the same in the urethra and in the bladder. With the measure of this pressure it is possible to diagnose prostatic obstruction (van Mastrigt et al, 2009). A multidisciplinary team from the Universidade Estadual de Campinas used the idea behind the condom catheter to create a new device: the urethral connector. This method is faster and cheaper when compared to the pressure flow study. Moreover, it reduces the risk of infections because it is non-invasive. In a clinical trial, there was 70% of total accuracy (D'Ancona et al, 2008). The present study will evaluate the efficacy of this new method by comparing its results to the International Prostate Symptom Score, the International Consultation on Incontinence Questionnaire Overactive Bladder and the results of lower urinary tract ultrasound. The statistical analysis will be made using the t-test and a multivariate analysis. Data will be collected from 80 participants who are in a clinical trial conducted by a multidisciplinary team in the Ambulatory care of Functional Urology in the Hospital de Clínicas da UNICAMP. ARNOLDS et al. Positioning invasive versus noninvasive urodynamics in the assessment of bladder outlet obstruction. Current Opinion in Urology. D'ANCONA et al. New method for minimally invasive urodynamic assessment in men with lower urinary tract symptoms. Journal of Urology. KUO et al. The role of intravesical prostatic protrusion (IPP) in the evaluation and and treatment of bladder outlet obstruction (BOO). Neurology and Urodynamics. VAN MASTRIGT et al. Development and application of the condom catheter method for non-invasive measurement of bladder pressure. Indian Journal of Urology. (AU)

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