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Study of metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by immuno-histochemistry

Grant number: 17/13167-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2017
Effective date (End): November 30, 2018
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal researcher:Fernanda Viviane Mariano Brum Corrêa
Grantee:Larissa Fernandes Rosa
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry, AP.JP

Abstract

The pleomorphic adenoma (PA) is the most common tumor of the salivary gland and although benign, it has chances of recurrence and malignant transformation to carcinoma ex pleomorphic adenoma (CXPA). The latter is an aggressive neoplasm occurring with metastasis and death in a large percentage of cases. Although both tumors have important discoveries in genetic and molecular areas, the changes found are focal and in specific genetic sites. There are still many questions about the diagnostic market, pathogenesis and target therapy of PA and CXPA. Since the pathogenesis of cancer is characterized by a complex mix of genetic and metabolic changes, we will study various metabolic pathways (glucogenesis, lipogenesis) through immune-histochemical markers. This way, in this project, we will study a group of PAs and CXPAs (subdivided according to histological type and degree of progression) through the immune-histochemical reaction. With this approach, analyzing metabolic changes involved in tumorigenesis PA, CXPA carcinogenesis and tumor progression, we intend to add knowledge to what is known today expecting to discovery markers for diagnosis, pathogenesis and target therapy. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SCARINI, JOAO FIGUEIRA; ROSA, LARISSA FERNANDES; DE LIMA SOUZA, REYDSON ALCIDES; ABU EGAL, ERIKA SAID; TINCANI, ALFIO JOSE; MARTINS, ANTONIO SANTOS; KOWALSKI, LUIZ PAULO; GRANER, EDGARD; DELLA COLETTA, RICARDO; CARLOS, ROMAN; GONDAK, ROGERIO DE OLIVEIRA; DE ALMEIDA, OSLEI PAES; DE ALMEIDA MILANI ALTEMANI, ALBINA MESSIAS; BASTOS, DEBORA CAMPANELLA; MARIANO, FERNANDA VIVIANE. Gene and immunohistochemical expression of HIF-1 alpha, GLUT-1, FASN, and adipophilin in carcinoma ex pleomorphic adenoma development. ORAL DISEASES, v. 26, n. 6 APR 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.