Development of polymer blends of latex-alginate and latex-collagen for tissue engineering application

• Grant number: 17/02518-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: December 01, 2017
• End date: May 31, 2020
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Rondinelli Donizetti Herculano
• Grantee: Natan Roberto de Barros
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated research grant: 16/01743-5 - The new gestational triad: hyperglycemia, urinary incontinence (UI) and biomolecular profile as a long-term predictor for UI: a prospective cohort study: translational research with biodevice with stem cells for muscle regeneration in diabetic rats, AP.TEM
• Associated scholarship(s): 18/11861-0 - Skin-on-a-chip model for drug treatment study, BE.EP.DR

Abstract

The natural rubber latex extracted from rubber tree Hevea brasiliensis have shown promising results in biomedical applications where membranes produced from this material have been used as medical prostheses and grafts due to their biocompatibility characteristics, bone growth and natural stimulation to angiogenesis. According to the literature, no in vivo work showed degradation of the latex during the experimental period. Thus, the objective of this work is the development and characterization of natural latex membranes functionalized with alginate / collagen for tissue engineering applications. In this way, it is expected to make possible the use of these new membranes based on natural latex also as prostheses, tissue grafts and systems of sustained release of bioactive compounds. For this purpose, physico-chemical and biological characterizations will be performed, which are commonly used in biomaterials and in dermal application.

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

DE BARROS, NATAN ROBERTO; CHAGAS, ANA LAURA DESTRO; FORSTER, SAMUEL; BRASIL, GIOVANA SANT'ANA PEGORIN; RIBEIRO, GERALDO MONTEIRO; OLIVATO, ORESTES PEREIRA; RAMALHO, LEANDRA NAIRA ZAMBELLI; GUERRA, NAYRIM BRIZUELA; MUSSAGY, CASSAMO USSEMANE; FLORIANO, JULIANA FERREIRA; et al. Novel highly flexible collagen-loaded latex dressing to treat diabetic foot ulcer: A pilot clinical trial. International Journal of Biological Macromolecules, v. 308, p. 20-pg., 2025-05-01. (17/19603-8, 11/17411-8, 23/17448-6, 17/02518-8, 18/07342-8)

BARROS, NATAN ROBERTO; AHADIAN, SAMAD; TEBON, PEYTON; CUNHA RUDGE, MARILZA VIEIRA; PASCON BARBOSA, ANGELICA MERCIA; HERCULANO, RONDINELLI DONIZETTI. Highly absorptive dressing composed of natural latex loaded with alginate for exudate control and healing of diabetic wounds. Materials Science & Engineering C-Materials for Biological Applications, v. 119, FEB 2021. (17/19603-8, 17/02518-8, 16/01743-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BARROS, Natan Roberto de. Development of latex-alginate and latex-collagen polymer blends for application in tissue engineering. 2020. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Química. Araraquara Araraquara.