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Comparative genomic analysis of Klebsiella pneumoniae belonging to the endemic high-risk clonal complex CC258 (ST11, ST437, ST340, ST258) in the Human-Animal-Environment Interface in Brazil

Grant number: 17/25909-2
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): February 12, 2018
Effective date (End): April 12, 2018
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal researcher:Nilton Erbet Lincopan Huenuman
Grantee:Louise Teixeira Cerdeira
Supervisor abroad: Kathryn Holt
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Melbourne, Australia  
Associated to the scholarship:15/21325-0 - Comparative analysis of the resistome of Klebsiella pneumoniae XDR (NDM-1/KPC-2) belonging to the endemic high-risk clonal complex CC258, BP.DR


Klebsiella pneumoniae is recognised as an urgent problem of public health worldwide, where the emergence and dissemination of multidrug-resistant (MDR) lineages has been associated with endemic clones producing hospital outbreaks and community-acquired infections. In this regard, K. pneumoniae clonal complex (CC) 258 (comprising STs 258, 11, 340, 437 and closely related variants) has been related with dissemination of the KPC-2 carbapenemase. Mobilization of blaKPC-2 gene has been supported by the horizontal transfer of Tn4401-type transposon carried on conjugative plasmids that contribute to the global success of high-risk clones. In Brazil, the rapid expansion of a virulent and carbapenem-resistant K. pneumoniae ST11 international high-risk clone has been documented, being associated with remarkable morbidity and mortality rates. Moreover, the presence of strains belonging to CC258 has been identified in human, food-production animals, urban aquatic environmental and recreational waters in metropolitan areas. The present study aims to perform a comparative genomic analysis of strains belonging to CC258 in the human-animal-environment interface, in Brazil, with further KPC-2 plasmid characterization.

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