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Comparative genomic analysis of Klebsiella pneumoniae belonging to the endemic high-risk clonal complex CC258 (ST11, ST437, ST340, ST258) in the Human-Animal-Environment Interface in Brazil

Grant number: 17/25909-2
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): February 12, 2018
Effective date (End): April 12, 2018
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal Investigator:Nilton Erbet Lincopan Huenuman
Grantee:Louise Teixeira Cerdeira
Supervisor: Kathryn Holt
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Melbourne, Australia  
Associated to the scholarship:15/21325-0 - Comparative analysis of the resistome of Klebsiella pneumoniae XDR (NDM-1/KPC-2) belonging to the endemic high-risk clonal complex CC258, BP.DR


Klebsiella pneumoniae is recognised as an urgent problem of public health worldwide, where the emergence and dissemination of multidrug-resistant (MDR) lineages has been associated with endemic clones producing hospital outbreaks and community-acquired infections. In this regard, K. pneumoniae clonal complex (CC) 258 (comprising STs 258, 11, 340, 437 and closely related variants) has been related with dissemination of the KPC-2 carbapenemase. Mobilization of blaKPC-2 gene has been supported by the horizontal transfer of Tn4401-type transposon carried on conjugative plasmids that contribute to the global success of high-risk clones. In Brazil, the rapid expansion of a virulent and carbapenem-resistant K. pneumoniae ST11 international high-risk clone has been documented, being associated with remarkable morbidity and mortality rates. Moreover, the presence of strains belonging to CC258 has been identified in human, food-production animals, urban aquatic environmental and recreational waters in metropolitan areas. The present study aims to perform a comparative genomic analysis of strains belonging to CC258 in the human-animal-environment interface, in Brazil, with further KPC-2 plasmid characterization.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CERDEIRA, LOUISE T.; LAM, MARGARET M. C.; WYRES, KELLY L.; WICK, RYAN R.; JUDD, LOUISE M.; LOPES, RALF; RIBAS, ROSINEIDE M.; MORAIS, MARCIA M.; HOLT, KATHRYN E.; LINCOPAN, NILTON. Small IncQ1 and Col-Like Plasmids Harboring bla(KPC-2) and Non-Tn4401 Elements (NTEKPC-IId) in High-Risk Lineages of Klebsiella pneumoniae CG258. Antimicrobial Agents and Chemotherapy, v. 63, n. 3, . (16/08593-9, 15/21325-0, 17/25909-2)

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