Study of macrophage modulation by extracellular vesicles of Sporothrix brasiliensis

• Grant number: 17/19916-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2017
• Effective date (End): November 30, 2018
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Karen Spadari Ferreira
• Grantee: Gabriela Ferrari Rugani
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

Sporotrichosis is an emerging mycosis that can affect the subcutaneous tissue, lymphatic system and other organs in humans and animals. It is a disease caused by a complex of at least four species and one of them is S. brasiliensis. Some fungi are able to release extracellular vesicles (VEs) that influence the immune response of the host. Macrophages are important phagocytic cells, therefore, study their interaction with these VEs of S brasiliensis contribute to understanding the pathogenesis of the disease, to seek new forms of therapy and diagnosis. (AU)