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Organocatalyzed synthesis of aziridine aldehydes and applications in multicomponent reactions

Grant number: 17/23867-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2018
Effective date (End): January 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Cooperation agreement: GlaxoSmithKline
Principal Investigator:Arlene Gonçalves Corrêa
Grantee:Allan Ribeiro da Silva
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock, AP.PCPE


The development of new environmentally correct technologies for the formation of C-C bonds a highly relevant topic for scientific society. In this view the multicomponent reactions are methodologies of great interest for their ability to generate multiple bonds in the presence of conditions that follow the principles of green chemistry. Regarding the CERSusChem interests this project proposes the development of a new organocatalysed technology for synthesis of enantiomerically pure aziridine aldehydes and their applications in Ugi and Petasis multicomponent reactions for obtaining chiral bioactive molecules. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, DEBORAH A.; DA SILVA, ALLAN R.; ELLENA, JAVIER; DA SILVA, CECILIA C. P.; PAIXAO, MARCIO W.; CORREA, ARLENE G. Green One-Pot Asymmetric Synthesis of Peptidomimetics via Sequential Organocatalyzed Aziridination and Passerini Multicomponent Reaction. SYNTHESIS-STUTTGART, v. 52, n. 7, p. 1076-1086, APR 1 2020. Web of Science Citations: 0.
DA SILVA, ALLAN RIBEIRO; DOS SANTOS, DEBORAH ARAUJO; PAIXAO, MARCIO WEBER; CORREA, ARLENE GONCALVES. Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines. Molecules, v. 24, n. 3 FEB 1 2019. Web of Science Citations: 3.

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