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Study of prostate cancer biomarkers by aptameric sensors

Grant number: 16/25749-2
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): February 01, 2018
Effective date (End): January 31, 2021
Field of knowledge:Biological Sciences - Biology
Principal Investigator:Gustavo Rocha de Castro
Grantee:Bruno Pereira Crulhas
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):18/16587-4 - Development of microfluidic cell cultures and Aptamer-based biosensors for monitoring drug responses of pancreatic cancer, BE.EP.PD


The prostate cancer is a worldwide disease with high mortality rate and traditional methods for diagnosis and monitoring are performed through invasive techniques. Currently, the advance of research in medical and biomedical engineering allowed the use of molecular tools combined with nanotechnology to develop portable biosensors specific for major biomarkers to diagnostic, monitoring and treatment of several diseases. More specifically, the cellular responses to biological, chemical or physical stimuli can be evaluated in microfluidic devices using electrochemical techniques. The objective of this project is the development of integrated biosensors to study different cell biomarkers released by prostate cancer cells, as: free prostatic specific antigen (fPSA), vascular endothelial growth factor (VEGF), mucin (MUC1), hexokinase type 2 (hK2), prostatic specific membrane antigen (PSMA), androgen receptor (AR) and prostatic acid phosphatase (PAP) and moreover, evaluate metabolic activity combined with drug delivery systems in a device where the cellular microenvironment can be precisely defined offering new insights into the molecular metabolism events and for clinical analysis patients with prostate cancer.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PARRA, JOAO P. R. L. L.; CRULHAS, BRUNO P.; BASSO, CAROLINE R.; DELELLA, FLAVIA K.; CASTRO, GUSTAVO R.; PEDROSA, VALBER A.. Using an Electrochemical Aptasensor to Early Detect Prostate Specific and Free Prostate Specific Antigens Released by Cancer Cells. Electroanalysis, v. 30, n. 12, p. 2869-2877, . (16/25749-2, 16/15919-8)
CRULHAS, BRUNO P.; BASSO, CAROLINE R.; PARRA, JOAO P. R. L. L.; CASTRO, GUSTAVO R.; PEDROSA, VALBER A.. Reduced Graphene Oxide Decorated with AuNPs as a New Aptamer-Based Biosensor for the Detection of Androgen Receptor from Prostate Cells. JOURNAL OF SENSORS, . (16/25749-2, 16/15919-8)

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