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Development of hybrid enzymatic cascade to produce an efficient ethanol/O2 biofuel cell

Grant number: 17/20431-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2018
Effective date (End): December 31, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Adalgisa Rodrigues de Andrade
Grantee:Jefferson Honorio Franco
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/50945-4 - INCT 2014: National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactivies, AP.TEM
Associated scholarship(s):18/24180-1 - Preparation of hybrid multi-catalyst architecture containing enzyme, organic catalyst and carbon nanotubes modified for complete ethanol electrochemical oxidation, BE.EP.PD


Biofuel cells are devices that use chemical reactions to produce energy using biological catalysts (enzymes or microorganisms), providing clean and renewable energy, and have great potential as alternative energy sources for low-power electronic devices. The characteristics of enzymatic biofuel cells are quite promising, however, they still present several challenges. Thus, some adjustments in the key development issues of this device are important objects of research, such as: (1) increase in the generated energy, (2) increase of electronic conductivity into the biofilms. Thus, the goal of this research project is the preparation of enzymatic bioanodes aiming the improvement of these points. For this, the oxidation of ethanol as a model fuel for hybrid bioanodes will be investigated in order to obtain the complete oxidation of this substrate, that is, use all chemical energy with utilization of maximum electrons available in the fuel. In parallel, to improve the eléctron transfer between the active center of the enzymes and the electrode will be constructed hybrid hydrogels using the linear polymer of ethyleneimine or linear polyethylenimine (LPEI) associated with the cross-linker agent ethylene glycol diglycidyl ether (EGDGE). The performance of the system can be improved by the presence or absence of modified carbon nanotubes with the subsequent addition of an organic catalyst (TEMPO-N-oxyl-2,2,6,6-tetramethylpiperidine), which is capable of oxidizing a wide range of functional groups containing oxygen, nitrogen and sulfur. The progress of hybrid enzymatic reaction will be monitored by electrochemical techniques, such as electrolysis, and analytical techniques, to identify and confirm possible products formed after the oxidation of the fuel.

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FRANCO, JEFFERSON HONORIO; GRATTIERI, MATTEO; DE ANDRADE, ADALGISA R.; MINTEER, SHELLEY D. Unveiling complete lactate oxidation through a hybrid catalytic cascade. Electrochimica Acta, v. 376, APR 20 2021. Web of Science Citations: 0.
FRANCO, JEFFERSON HONORIO; MINTEER, SHELLEY D.; DE ANDRADE, ADALGISA R. Ethanol Biofuel Cells: Hybrid Catalytic Cascades as a Tool for Biosensor Devices. BIOSENSORS-BASEL, v. 11, n. 2 FEB 2021. Web of Science Citations: 0.
FRANCO, JEFFERSON HONORIO; KLUNDER, KEVIN J.; LEE, JACK; RUSSELL, VICTORIA; DE ANDRADE, ADALGISA R.; MINTEER, SHELLEY D. Enhanced electrochemical oxidation of ethanol using a hybrid catalyst cascade architecture containing pyrene-TEMPO, oxalate decarboxylase and carboxylated multi-walled carbon nanotube. BIOSENSORS & BIOELECTRONICS, v. 154, APR 15 2020. Web of Science Citations: 0.
FRANCO, JEFFERSON HONORIO; KLUNDER, KEVIN J.; RUSSELL, VICTORIA; DE ANDRADE, ADALGISA R.; MINTEER, SHELLEY D. Hybrid enzymatic and organic catalyst cascade for enhanced complete oxidation of ethanol in an electrochemical micro-reactor device. Electrochimica Acta, v. 331, JAN 20 2020. Web of Science Citations: 0.
FRANCO, JEFFERSON HONORIO; DE ALMEIDA, PAULA ZAGHETTO; ABDELLAOUI, SOFIENE; HICKEY, DAVID P.; CIANCAGLINI, PIETRO; POLIZELI, MARIA DE LOURDES T. M.; MINTEER, SHELLEY D.; DE ANDRADE, ADALGISA R. Bioinspired architecture of a hybrid bifunctional enzymatic/organic electrocatalyst for complete ethanol oxidation. BIOELECTROCHEMISTRY, v. 130, DEC 2019. Web of Science Citations: 1.
FRANCO, JEFFERSON HONORIO; AQUINO NETO, SIDNEY; HICKEY, DAVID P.; MINTEER, SHELLEY D.; DE ANDRADE, ADALGISA R. Hybrid catalyst cascade architecture enhancement for complete ethanol electrochemical oxidation. BIOSENSORS & BIOELECTRONICS, v. 121, p. 281-286, DEC 15 2018. Web of Science Citations: 4.
FRANCO, JEFFERSON HONORIO; MINTEER, SHELLEY D.; DE ANDRADE, ADALGISA R. Product Analysis of Operating an Ethanol/O-2 Biofuel Cell Shows the Synergy between Enzymes within an Enzymatic Cascade. Journal of the Electrochemical Society, v. 165, n. 9, p. H575-H579, 2018. Web of Science Citations: 5.

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