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Scales of biodiversity: integrated studies of snake evolution and venom function

Grant number: 17/24546-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): February 01, 2018
Effective date (End): May 31, 2022
Field of knowledge:Biological Sciences - Biology
Cooperation agreement: NSF - Dimensions of Biodiversity and BIOTA
Principal researcher:Ana Maria Moura da Silva
Grantee:Luciana Aparecida Freitas de Sousa
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:16/50127-5 - Dimensions US-BIOTA São Paulo: scales of biodiversity: integrated studies of snake venom evolution and function across multiple levels of diversity, AP.BTA.TEM
Associated scholarship(s):18/08589-7 - Mechanisms involved in the phenotype variability of venoms from snakes from the same group (Bothrops), BE.EP.PD

Abstract

Proteolytic enzymes and phospholipases are key components in the venom of snakes, especially in viperids. They are involved in the capture and digestion of prey acting on several targets important for the control of hemostasis and also contribute to the digestion of tissues. In this project, we will evaluate the activities of phospholipases, serine proteinases and metalloproteinases in the venom samples of all the individuals collected in the 120 species included in the project, correlating these data with the phylogenetic analyzes in progress by the other groups. The venoms highly expressing these enzymes will be selected and tested for their digestive properties of the tissues of mammalian prey, lizards and arthropods and will be used for pharmacological approaches to identify disorders of the hemostatic system that they induce and their main mechanisms of action. These data will be fundamental for a better understanding of the relevance of the functional characteristics of the venom components to the snake speciation and evolution process. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BAYONA-SERRANO, JUAN DAVID; VIALA, VINCENT LOUIS; RAUTSAW, RHETT M.; SCHRAMER, TRISTAN D.; BARROS-CARVALHO, GESIELE A.; NISHIYAMA, JR., MILTON YUTAKA; FREITAS-DE-SOUSA, LUCIANA A.; MOURA-DA-SILVA, ANA MARIA; PARKINSON, CHRISTOPHER L.; GRAZZIOTIN, FELIPE GOBBI; JUNQUEIRA-DE-AZEVEDO, INACIO L. M. Replacement and Parallel Simplification of Nonhomologous Proteinases Maintain Venom Phenotypes in Rear-Fanged Snakes. Molecular Biology and Evolution, v. 37, n. 12, p. 3563-3575, DEC 2020. Web of Science Citations: 1.
FREITAS-DE-SOUSA, LUCIANA A.; NACHTIGALL, PEDRO G.; FORTES-JUNIOR, JOSE A.; HOLDING, MATTHEW L.; NYSTROM, GUNNAR S.; ELLSWORTH, SCHYLER A.; GUIMARIES, NORANATHAN C.; TIOYAMA, EMILLY; ORTIZ, FLORA; SILVA, BRUNO R.; KUNZ, TOBIAS S.; JUNQUEIRA-DE-AZEVEDO, INICIO L. M.; GRAZZIOTIN, FELIPE G.; ROKYTA, DARIN R.; MOURA-DA-SILVA, ANA M. Size Matters: An Evaluation of the Molecular Basis of Ontogenetic Modifications in the Composition of Bothrops jararacussu Snake Venom. TOXINS, v. 12, n. 12 DEC 2020. Web of Science Citations: 0.
S. OLIVEIRA, SAMELLA; C. ALVES, ELIANE; S. SANTOS, ALESSANDRA; F. NASCIMENTO, ELIZANDRA; T. PEREIRA, JOAO PEDRO; M. SILVA, IRAN; A. G. SACHETT, JACQUELINE; S. SARRAFF, LYBIA KASSIA; FREITAS-DE-SOUSA, LUCIANA APARECIDA; COLOMBINI, MONICA; O. MARQUES, HEDYLAMAR; V. G. LACERDA, MARCUS; SARTIM, MARCO AURELIO; MOURA-DA-SILVA, ANA MARIA; L. FERREIRA, LUIZ CARLOS; S. SANO-MARTINS, IDA; M. MONTEIRO, WUELTON. Bleeding Disorders inBothrops atroxEnvenomations in the Brazilian Amazon: Participation of Hemostatic Factors and the Impact of Tissue Factor. TOXINS, v. 12, n. 9 SEP 2020. Web of Science Citations: 0.
MOURA-DA-SILVA, ANA MARIA; CONTRERAS-BERNAL, JORGE CARLOS; GIMENES, SARAH NATALIE CIRILO; FREITAS-DE-SOUSA, LUCIANA APARECIDA; PORTES-JUNIOR, JOSE ANTONIO; PEIXOTO, PEDRO DA SILVA; IWAI, LEO KEI; DE MOURA, VALERIA MOURAO; BISNETO, PEDRO FERREIRA; LACERDA, MARCUS; DA SILVA, IRAN MENDONCA; FERREIRA, LUIZ CARLOS DE LIMA; DE OLIVEIRA, SAMELLA SILVA; WEN, FAN HUI; SACHETT, JACQUELINE DE ALMEIDA GONCALVES; MONTEIRO, WUELTON M. The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox). PLoS Neglected Tropical Diseases, v. 14, n. 6 JUN 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.