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THE ACTION OF MARESIN 1 (MAR1) ON FIBROGENESIS AND OSTEOGENIC ACTIVITY OF HUMAN PERIODONTAL LIGAMENT CELLS

Grant number: 17/25260-6
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 30, 2018
Effective date (End): March 29, 2019
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Marinella Holzhausen Caldeira
Grantee:Emmanuel Albuquerque de Souza
Supervisor abroad: Alpdogan Kantarci
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Forsyth Institute, United States  
Associated to the scholarship:16/14687-6 - Evaluation of immunomodulatory potential of probiotics in periodontal disease, BP.DR

Abstract

Maresins (macrophage mediators in resolving inflammation) are a family of specialized proresolving mediators of macrophage origin. These mediators are biosynthesized via initial lipoxygenation and molecular oxygen insertion at the carbon 14 position of docosahexaenoic acid (DHA) followed by epoxidation and oxygen incorporation at the carbon 7 position from a molecule of H2O. This research will evaluate how the maresin 1 (MaR1) can act on fibrogenesis and osteonenic activity of human periodontal ligament cells (hPDLCs) in an inflammatory microenvironment with cytokines IL-1² and TNF-±. Thus, we will evaluate the action of such mediators on the synthesis and gene expression of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), as well as its effects on collagen and osteogenic activity through alizarin red S staining and picro-sirius red staining. We will also perform analyzes about the expression of genes related to the periodontal ligament metabolism [(MMP-1, MMP-8, MMP-13, MMP-2, MMP-9, TIMP-1, TMIP-2, COL-1, ALP, osteopontin (OP), Periostin (PTN)], and the action of MaR1 on the phosphorylation of signal transduction molecules (MAPK and NF-ºB).

News published in Agência FAPESP Newsletter about the scholarship:
Molecules derived from omega-3 can regenerate inflamed periodontal tissue 
Articles published in other media outlets (19 total):
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Santé blog (França): PARODONTITE : Les omega-3 pour régénérer la gencive (23/Dec/2020)
Mindzilla (Reino Unido): Molecules Derived from Omega-3 can Regenerate Inflamed Periodontal Tissue (17/Dec/2020)
Today News Post (EUA): Molecules derived from omega-3 can regenerate inflamed periodontal tissue (17/Dec/2020)
Globe Health News: Lipid mediators can enhance regeneration of inflamed periodontal tissue (17/Dec/2020)
Nature BIO1000 (China): 源自omega3的分子可再生牙周组织发炎 (17/Dec/2020)
News Medical (Austrália): Lipid mediators can enhance regeneration of inflamed periodontal tissue (16/Dec/2020)
Bioengineer (Reino Unido): Molecules derived from omega-3 can regenerate inflamed periodontal tissue (16/Dec/2020)
Science Codex: Molecules derived from omega-3 can regenerate inflamed periodontal tissue (16/Dec/2020)
Republish (Índia): Molecules derived from omega-3 can regenerate inflamed periodontal tissue (16/Dec/2020)
Dentistry Today (EUA) online: Molecules Derived from Omega-3 Can Regenerate Inflamed Periodontal Tissue (16/Dec/2020)
Sound Health and Lasting Wealth (Nigéria): Lipid mediators can enhance regeneration of inflamed periodontal tissue (16/Dec/2020)
Biotech Asia News (Índia): Molecules derived from omega-3 can regenerate inflamed periodontal tissue (16/Dec/2020)
Hola PTY! (Panamá): Los mediadores de lípidos pueden mejorar la regeneración del tejido periodontal inflamado (16/Dec/2020)
Great Breaking News: Lipid mediators can enhance regeneration of inflamed periodontal tissue (16/Dec/2020)
Revista Analytica online: Moléculas derivadas do ômega-3 podem regenerar tecido periodontal (20/Nov/2020)
Programa InfoSalud (Argentina): Moléculas derivadas de omega-3 pueden regenerar tejido periodontal (16/Nov/2020)
Plantão News (MT): Moléculas derivadas do ômega-3 podem regenerar tecido periodontal (14/Nov/2020)
Revista Amazônia: Moléculas derivadas do ômega-3 podem regenerar tecido periodontal (13/Nov/2020)
Portal da Enfermagem: Moléculas derivadas do ômega-3 podem regenerar tecido periodontal (13/Nov/2020)