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Study about the level of FGF21 on liver and adipose tissue after hepatic surgery in diabetic and healthy mice

Grant number: 17/23467-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2018
Effective date (End): April 30, 2018
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Mariana Mendes Braz
Grantee:Jéssica Caroline Figueiredo
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Introduction: Ischemia/reperfusion injury (I/R) occurs in a number of clinical situations, including hepatic resection (PH). Diabetes mellitus (DM) is an important risk factor for many surgical complications. It is associated with poor prognosis of I/R injury and impairs the liver ability to regenerate. Fibroblast growth factors (FGFs) are a group of proteins that stimulate a wide variety of cell types. Although the importance of liver is widely reported both in production and in action of FGF21, this cytokine has been presented as a stress sign among different tissue. Aim: to identify the production of FGF21 in liver and the relevance of white adipose tissue as source of FGF21 in the context of PH under I/R in diabetic and healthy mice. We will also analyze I/R damage and regeneration in livers submitted PH under I/R and the relationship between liver injury, regeneration and FGF21 levels. Materials and Methods: The analyzes will be performed on samples (liver, plasma and adipose tissue) collected from healthy and diabetic (alloxan, 60 mg / kg, i.v.) mice submitted to PH under I/R. (AU)