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MicroRNAs in stool and platelets biology from gastroenterology cancer patient samples that correlate with ACP1 protein tyrosine phosphatase: colorectal cancer screening

Grant number: 18/00736-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): February 25, 2018
Effective date (End): February 24, 2019
Field of knowledge:Biological Sciences - Biochemistry - Enzymology
Principal researcher:Carmen Veríssima Ferreira
Grantee:Alessandra Valéria de Sousa Faria
Supervisor abroad: Maikel Peppelenbosch
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: Erasmus University Rotterdam (EUR), Netherlands  
Associated to the scholarship:17/08119-8 - Hematogenous tumor metastasis in colon rectal cancer cells: influence of LMWPTP and 3-bromopyruvate, BP.DR


The success of cancer prevention and treatment involves efficiency diagnosis and therapy. Over the past years, the Prof. Ferreira-Halder and Prof. Peppelenbosch research groups have investigated cancer cells metabolism to clarify resistance and aggressiveness processes. It was found a correlation between resistance/aggressiveness in leukemia, prostate and colorectal cancer (CRC) and high expression of Low Weight Molecular Protein Tyrosine Phosphatase (LMWPTP). This proposal will address two important points in cancer field: validation of a newbiomarker (LMWPTP and/or molecules related to LMWPTP) and biological characterization of a small molecule (3-bromopyruvate) that has a potential to re-educate platelets and consequently, inhibits the first step ofhematogenous dissemination of CRC cells. Therefore, the aims will cover: 1) for diagnosis: identify LMWPTP ormiRNAs modulated by this enzyme in fecal samples from patients and used it as a biomarker. Since, the mostused diagnostic testing for colorectal cancer has low sensitivity (fecal occult blood testing), or it is expensive andinvasiveness (colonoscopy), new biomarker that overcomes these problems is urgently needed; and 2) fordecreasing metastasis efficiency: 3-bromopyruvate is able to decrease the interaction between CRC cellsplatelets.This finding indicates that this small molecule has a greater potential to block the metastasis. At this stage, we will scrutinize the molecular mechanism by which it occurs. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FARIA, ALESSANDRA V. S.; YU, BINGTING; MOMMERSTEEG, MICHIEL; DE SOUZA-OLIVEIRA, PATRICIA F.; ANDRADE, SHEILA S.; SPAANDER, MANON C. W.; DE MAAT, MONIEK P. M.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, V, CARMEN; FUHLER, GWENNY M.. Platelet-dependent signaling and Low Molecular Weight Protein Tyrosine Phosphatase expression promote aggressive phenotypic changes in gastrointestinal cancer cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 1868, n. 1, . (17/26317-1, 18/00736-0, 16/14459-3, 17/08119-8, 15/20412-7)
FARIA, ALESSANDRA V. S.; ANDRADE, SHEILA S.; REIJM, AGNES N.; SPAANDER, MANON C. W.; DE MAAT, MONIEK P. M.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, V, CARMEN; FUHLER, GWENNY M.. Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients. JOURNAL OF CLINICAL MEDICINE, v. 8, n. 7, . (17/08119-8, 18/00736-0, 15/20412-7)
FARIA, ALESSANDRA V. S.; ANDRADE, SHEILA S.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, CARMEN V.; FUHLER, GWENNY M.. Platelets in aging and cancer-{''}double-edged sword{''}. CANCER AND METASTASIS REVIEWS, v. 39, n. 4, SI, . (17/08119-8, 17/26317-1, 16/14459-3, 15/20412-7, 18/00736-0)
FARIA, ALESSANDRA V. DE S.; AKYALA, ADAMU ISHAKU; PARIKH, KAUSHAL; BRUEGGEMANN, LOIS W.; SPEK, C. ARNOLD; CAO, WANLU; BRUNO, MARCO J.; BIJLSMA, MAARTEN F.; FUHLER, GWENNY M.; PEPPELENBOSCH, MAIKEL P.. Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling. Journal of Biological Chemistry, v. 294, n. 25, p. 9787-9798, . (18/00736-0)
FARIA, ALESSANDRA V. S.; ANDRADE, SHEILA S.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, V, CARMEN; FUHLER, GWENNY M.. The role of phospho-tyrosine signaling in platelet biology and hemostasis. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1868, n. 3, . (15/20412-7, 17/26317-1, 17/08119-8, 16/14459-3, 18/00736-0)

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