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Zika virus in postpartum women and newborns: seroepidemiology and molecular characterization

Grant number: 17/24769-2
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): January 01, 2018
Effective date (End): November 30, 2022
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal researcher:Edison Luiz Durigon
Grantee:Rafael Rahal Guaragna Machado
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/20045-7 - Antigen discovery and development of serological diagnostic methods and vaccine approaches against the Zika Virus (ZIKV), AP.TEM
Associated scholarship(s):19/27803-2 - Immune-mediated mayaro virus protection from wild-type chikungunya virus infection, BE.EP.DD

Abstract

The Zika Virus (ZIKV) is an arbovirus belonging to the family Flaviviridae, genus Flavivirus. Arboviruses are viruses characterized by being kept in the wild in enzootic cycles, involving hematophagous arthropod vectors and may participate in an urban cycle in which humans are the main hosts. In 2015, there was an epidemiological outbreak of ZIKV in Brazil, which is considered by the World Health Organization as an emergency public health emergency pathogen of international concern. In addition to the mode of vector transmission, by species of the genus Aedes, other non-vector transmission media have already been reported, such as sexual, vertical, transfusional, saliva and urine transmission. About 80% of cases of ZIKV infection are asymptomatic and, when present, clinical manifestations are very similar to other arbovirus infections, making the diagnosis of this disease a major challenge. Currently, even though several clinical complications are known, following the ZIKV infection, few studies aimed to investigate the serological profile of these patients. Therefore, this project aims to conduct a prospective/descriptive/epidemiological study, aiming to investigate the frequency of ZIKV infection in puerperae and neonates, determining their serological profile and the molecular characterization of the Zika virus. This study is based on the importance of understanding the full scope of the effect of Zika virus in pregnancy, since it has not been elucidated yet, besides the need for epidemiological data that can help guide the medical and public health responses to this arbovirose. (AU)

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Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MENDRONE-JUNIOR, ALFREDO; DINARDO, CARLA LUANA; FERREIRA, SUZETE CLEUZA; NISHYA, ANNA; SALLES, NANCI ALVES; DE ALMEIDA NETO, CESAR; HAMASAKI, DEBORA TOSHEI; FACINCANI, TILA; DE OLIVEIRA ALVES, LUCAS BASSOLLI; MACHADO, RAFAEL RAHAL GUARAGNA; et al. Correlation between SARS-COV-2 antibody screening by immunoassay and neutralizing antibody testing. Transfusion, v. 61, n. 4, p. 1181-1190, . (16/20045-7, 20/06409-1, 17/24769-2)
WENDEL, SILVANO; KUTNER, JOSE MAURO; MACHADO, RAFAEL; FONTAO-WENDEL, RITA; BUB, CAROLINA; FACHINI, ROBERTA; YOKOYAMA, ANA; CANDELARIA, GABRIELA; SAKASHITA, ARACI; ACHKAR, RUTH; et al. Screening forSARS-CoV-2 antibodies in convalescent plasma in Brazil: Preliminary lessons from a voluntary convalescent donor program. Transfusion, v. 60, n. 12, p. 2938-2951, . (17/24769-2, 16/20045-7, 18/23680-0, 20/06409-1)
DANIELLE BASTOS ARAUJO; RAFAEL RAHAL GUARAGNA MACHADO; DEYVID EMANUEL AMGARTEN; FERNANDA DE MELLO MALTA; GABRIEL GUARANY DE ARAUJO; CAIRO OLIVEIRA MONTEIRO; ERIKA DONIZETTI CANDIDO; CAMILA PEREIRA SOARES; FERNANDO GATTI DE MENEZES; ANA CAROLINA CORNACHIONI PIRES; et al. SARS-CoV-2 isolation from the first reported patients in Brazil and establishment of a coordinated task network. Memórias do Instituto Oswaldo Cruz, v. 115, . (20/04680-0, 18/21076-9, 20/06409-1, 17/24769-2, 18/23680-0, 16/20045-7, 17/25123-9)
VENCESLAU-CARVALHO, ALEXIA ADRIANNE; FAVARO, MARIANNA TEIXEIRA DE PINHO; PEREIRA, LENNON RAMOS; RODRIGUES-JESUS, MONICA JOSIANE; PEREIRA, SAMUEL SANTOS; ANDREATA-SANTOS, ROBERT; ALVES, RUBENS PRINCE DOS SANTOS; CASTRO-AMARANTE, MARIA FERNANDA; RODRIGUES, KARINE BITENCOURT; DA SILVA, JAMILE RAMOS; et al. Nano-multilamellar lipid vesicles loaded with a recombinant form of the chikungunya virus E2 protein improve the induction of virus-neutralizing antibodies. Nanomedicine-Nanotechnology Biology and Medicine, v. 37, . (17/23281-6, 16/19145-7, 16/08204-2, 17/24769-2, 16/20045-7, 16/23560-0)
WENDEL, SILVANO; FONTAO-WENDEL, RITA; FACHINI, ROBERTA; CANDELARIA, GABRIELA; SCURACCHIO, PATRICIA; ACHKAR, RUTH; BRITO, MAYRA; REIS, LUIZ FERNANDO; CAMARGO, ANAMARIA; AMANO, MARIANE; et al. A longitudinal study of convalescent plasma (CCP) donors and correlation of ABO group, initial neutralizing antibodies (nAb), and body mass index (BMI) with nAb and anti-nucleocapsid (NP) SARS-CoV-2 antibody kinetics: Proposals for better quality of CCP collections. Transfusion, v. 61, n. 5, . (17/24769-2, 16/20045-7, 18/23680-0, 20/06409-1)
LOPES, ALESSANDRA G. D.; CELESTINO, CAMILA S. H.; BARROS, TIAGO T. A.; FEVEREIRO, ALINE G.; GEJER, DEBORA H.; OLIVEIRA, FERNANDO M. F.; BRASIL, JAMILE M.; BOSSOLAN, ROSELY M.; PINTO, GABRIELA C. C.; SANTOS, ANA C. E. Z.; et al. Case Report: A Severe SARS-CoV-2 Infection in a Teenager With Angelman Syndrome. FRONTIERS IN MEDICINE, v. 8, . (17/24769-2, 20/06409-1)
DE FREITAS DUTRA, VALERIA; BONET-BUB, CAROLINA; YOKOYAMA, ANA PAULA H.; ACHKAR, RUTH; MACHADO, RAFAEL RAHAL GUARAGNA; ASSUNCAO, MURILO; CANDELARIA, GABRIELA; SOARES, CAMILA PEREIRA; FACHINI, ROBERTA MARIA; FONTAO-WENDEL, RITA; et al. Anti-A and SARS-CoV-2: an intriguing association. Vox Sanguinis, v. 116, n. 5, . (17/24769-2, 16/20045-7, 18/23680-0, 20/06409-1)
SABINO, CAETANO P.; SELLERA, FABIO P.; SALES-MEDINA, DOUGLAS F.; GUARAGNA MACHADO, RAFAEL RAHAL; DURIGON, EDISON LUIZ; FREITAS-JUNIOR, LUCIO H.; RIBEIRO, MARTHA S.. UV-C (254 nm) lethal doses for SARS-CoV-2. Photodiagnosis and Photodynamic Therapy, v. 32, . (17/24769-2, 17/22406-0, 16/20045-7)
DORLASS, ERICK GUSTAVO; MONTEIRO, CAIRO OLIVEIRA; VIANA, AMANDA OLIVEIRA; SOARES, CAMILA PEREIRA; GUARAGNA MACHADO, RAFAEL RAHAL; THOMAZELLI, LUCIANO MATSUMIYA; ARAUJO, DANIELLE BASTOS; LEAL, FABYANO BRUNO; CANDIDO, ERIKA DONIZETTE; TELEZYNSKI, BRUNA LAROTONDA; et al. Lower cost alternatives for molecular diagnosis of COVID-19: conventional RT-PCR and SYBR Green-based RT-qPCR. Brazilian Journal of Microbiology, v. 51, n. 3, . (17/25123-9, 16/20045-7, 18/23680-0, 17/24769-2)
MACHADO, RAFAEL R. G.; GLASER, TALITA; ARAUJO, DANIELLE B.; PETIZ, LYVIA LINTZMAIER; OLIVEIRA, DANIELLE B. L.; DURIGON, GIULIANA S.; LEAL, ALESSANDRA L.; PINHO, JOAO RENATO R.; FERREIRA, LUIS C. S.; ULRICH, HENNING; et al. Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 Replication by Hypertonic Saline Solution in Lung and Kidney Epithelial Cells. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, v. 4, n. 5, p. 1514-1527, . (20/06409-1, 19/00195-2, 18/07366-4, 17/24769-2, 16/20045-7, 20/04680-0)
WENDEL, SILVANO; FACHINI, ROBERTA; FONTAO-WENDEL, RITA C. L.; MELLO, RALYRIA; VELASQUEZ, CARLOS VINICIUS; GUARAGNA MACHADO, RAFAEL RAHAL; BRITO, MAYRA ALTOBELLI; AMARAL, MARCELO; SOARES, CAMILA PEREIRA; ACHKAR, RUTH; et al. urrogate test performance for SARS-CoV-2 neutralizing antibodies (nAbs) for convalescent plasma (CCP): How useful could they be. Transfusion, v. 61, n. 12, . (17/24769-2, 20/06409-1, 16/20045-7, 18/23680-0)

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