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Histological and histomorphometric evaluation of autogenous and xenogenic onlay bone grafts: experimental study on rabbits mandibles

Grant number: 17/24969-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2018
Effective date (End): February 28, 2019
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal researcher:Samuel Porfirio Xavier
Grantee:Lucas Barros Chaves
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The search for bone substitutes has increased substantially in recent years. In this scenario, xenogenic bone has been used for alveolar ridge augmentation as alternative to decrease the disadvantages of the autogenous bone grafting procedures. The objectives of this work are: 1) to investigate the histological characteristics of block xenogenous bone grafts in rabbit mandible; 2) to compare, through histomorphometric measurements, autogenous and xenogenic grafts incorporation and remodeling processes. Thirty-six adult male New Zealand White rabbits, weighing 3.5 to 4.0 kg, underwent mandibular onlay graft surgery bilaterally. The animals were divided into two groups: Group I - grafting with autogenous bone blocks (n = 6); Group II - (n = 6) grafting with xenogen bone blocks. Six evaluation periods will be used, with sacrifice scheduled for: 7, 20 and 60 days after surgery. For histological and morphometric analisys, the following structures will be evaluated: neoformed bone, residual autogenous bone, remaining xenogenous bone, connective tissue and other relevant findings. The obtained data will be statistically analyzed by ANOVA, and Student's t test and Mann-Whitney test. (AU)

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