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Evaluation of biomarkers of exposure to mycotoxins in infants in the region of Ribeirão Preto/SP

Grant number: 17/12956-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2018
Effective date (End): December 31, 2019
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Engineering
Principal Investigator:Carlos Augusto Fernandes de Oliveira
Grantee:Carolina Fernanda Sengling Cebin Coppa
Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil


Mycotoxins are secondary metabolites produced by naturally occurring fungi in foods that are capable of causing a wide variety of toxic effects in vertebrates, including humans. The risk assessment of chemical substances such as mycotoxins should be based on the determination of the degree of human exposure through diet. Lactating women constitute an important risk group considering not only the potential toxic effects of mycotoxins but also the possibility of excretion of mycotoxin residues in breast milk. Several mycotoxins can be excreted in milk in their original or biotransformed form, but aflatoxin M1 (AFM1) is the main compound that can be found in breast milk due to the consumption of food contaminated with aflatoxin B1, leading, therefore, to the exposure of infants through breastfeeding. Available data on toxicokinetics of various mycotoxins in animal models indicate that exposure to mycotoxins can be measured by biomarkers in human urine. In recent years, liquid chromatography coupled to mass spectrometry (LC-MS/MS) based on the multi-analyte approach has been successfully introduced in the field of mycotoxin analysis, including evaluation of appropriate biomarkers for human exposure to mycotoxins. The aim of this project is to use LC-MS/MS analytical methods to evaluate the exposure of infants to aflatoxins (AFB1, AFB2, AFG1 and AFG2), fumonisins (FB1 and FB2), ochratoxin A (OTA), zearalenone (ZEA) and (AFM1, AFP1, AFQ1, FB1, OTA, DON, DOM-1, ZEA, ±- e ²-ZOL) in the urine and breast milk of volunteers from the Ribeirão Preto region, State of São Paulo. Therefore, the project will provide unpublished data on the simultaneous human exposure of infants to the main mycotoxins that occur in Brazil, evaluated through biomarkers in urine and milk, as well as their relation with the estimated mycotoxin intake in food. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COPPA, CAROLINA F. S. C.; CIRELLI, AMANDA C.; GONCALVES, BRUNA L.; BARNABE, ELIANA M. B.; PETTA, TANIA; FRANCO, LARISSA T.; JAVANMARDI, FARDIN; KHANEGHAH, AMIN MOUSAVI; LEE, I, SARAH H.; CORASSIN, CARLOS H.; et al. Mycotoxin occurrence in breast milk and exposure estimation of lactating mothers using urinary biomarkers in Sao Paulo, Brazil. Environmental Pollution, v. 279, . (19/21603-1, 17/12956-2)
KHANEGHAH, AMIN MOUSAVI; KAMANI, MOHAMMAD HASSAN; FAKHRI, YADOLAH; SENGLING CEBIN COPPA, CAROLINA FERNANDA; FERNANDES DE OLIVEIRA, CARLOS AUGUSTO; SANT'ANA, ANDERSON S.. Changes in masked forms of deoxynivalenol and their co-occurrence with culmorin in cereal-based products: A systematic review and meta-analysis. Food Chemistry, v. 294, p. 587-596, . (17/12956-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
COPPA, Carolina Fernanda Sengling Cebin. Exposure assessment and health risk characterization of mycotoxins in lactating women from Pirassununga/SP. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Zootecnica e Engenharia de Alimentos (FZE/BT) Pirassununga.

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