| Grant number: | 17/22405-3 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | March 01, 2018 |
| End date: | May 31, 2022 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Organic Chemistry |
| Principal Investigator: | Mario Sergio Palma |
| Grantee: | Amilcar Perez Riverol |
| Host Institution: | Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil |
| Associated research grant: | 16/16212-5 - Natural proteopeptides from the Brazilian fauna, flora and microbiota as potential models for the rational development of new drugs of therapeutic use: isolation, structure elucidation, chemical synthesis and functional activity assays, AP.BTA.TEM |
| Associated scholarship(s): | 18/24834-1 - Synthetic B-cell linear epitopes of allergens from clinically relevant Hymenoptera for improved molecular diagnosis and immunotherapy of venom allergy, BE.EP.PD |
Abstract Insect venom hypersensitivity is one of the leading causes of anaphylaxis in Brazil. Despite the great diversity of clinically relevant species identified in the country, no venom individual components obtained from endemic species are available for diagnosis and immunotherapy of allergy. Molecular characterization of insect venom allergens and particularly of the B-cells linear epitopes in their structures could allow the rational design of component-resolved diagnosis (CRD) and immunotherapy (CRIT). The use of these novel approaches could improve the identification of the culprit venom and the success of the specific treatment. In this study, a B-cell linear epitopes mapping in venom allergens from clinically relevant Brazilian insects, their in vitro synthesis, along with the structural and immunological characterization, will be conducted. The study will include in silico modelling and evaluation of IgG and IgE-mediated immunodetection by sera from allergic patients. Comprehensive analyses of peptipe-based cross-reactivity among allergens from different groups of insects will be performed. The results derived from the study will allowed the description of the molecular basis of the alergenicity of the venom from the analyzed insects. The characterized epitopes could be used as Subfamily-specific markers of allergy, a remained challenge for Hymenoptera venom allergy diagnosis worldwide. Finally, the identification and production of the relevant epitopes as synthetic peptides could lead to the development of novel commercial system for CRD and peptide-based IT, overall improving the Brazilian allergic patients' quality of life. | |
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