Influence of galantamine in the inflammatory process and tissular lesion caused by Trypanosoma cruzi QM2 strain

• Grant number: 17/08606-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2018
• End date: February 28, 2019
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Luciamare Perinetti Alves Martins
• Grantee: Lucas Fadel Camargo
• Host Institution: Faculdade de Medicina de Marília (FAMEMA). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). Marília , SP, Brazil

Abstract

Chagas disease is an infectious disease caused by Trypanosoma cruzi protozoan, classified by the World Health Organization not only as a neglected infirmity, but as also a public health issue in Latin America. This character is mainly due the relevance of prevention in the control of the disease, since its treatment still shows itself in a very challenging way. Despite the fact that the main presentation of the disease is the cardiac form - affecting directly the myocardium - there may be injuries in organs as the esophagus and colon in its digestive form, leading to damage in the gastrointestinal nervous plexi, impairing its tonus and peristalsis and, consequently, the carrier's life quality. Knowing that this plexi presents cholinergic transmission, the comprehension of the role of the anti-inflammatory cholinergic reflex is a matter of great concern, by which the vagus nerve releases acetylcholine locally, consequently inhibiting and attenuating inflammatory response by reducing the levels of cytokines like TNF-± and IL-1, 6 and 8. Thereby, this study intends to investigate the influence of an anticholinesterasic drug as galantamine in the treatment of the digestive form of Chagas disease in Swiss mice infected by T. cruzi QM2 strain. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LUCAS FADEL CAMARGO; GUILHERME DONZALISKY PINHEIRO; PRISCILLA BIANCA DE OLIVEIRA; DANIELE MORAES LOSADA; EDUARDO FEDERIGHI BAISI CHAGAS; MÁRCIA APARECIDA SPERANÇA; AGNALDO BRUNO CHIES; MARIA ANGÉLICA SPADELLA; LUCIAMÁRE PERINETTI ALVES MARTINS. Influence of galantamine in the inflammatory process and tissular lesions caused by Trypanosoma cruzi QM2 strain. Revista da Sociedade Brasileira de Medicina Tropical, v. 54, 2021-11-12. (17/08606-6, 09/09788-4)