Residual persistence investigation of toxic constituents of C. duckei used in Pisciculture

• Grant number: 17/15052-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2018
• End date: February 29, 2020
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Jonas Augusto Rizzato Paschoal
• Grantee: Jonas Joaquim Mangabeira da Silva
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 12/18334-0 - Veterinary drug residues in food: multiclass analytical methods employing LC-MS/MS, exposition data and residual depletion study, AP.JP

Abstract

The use of veterinary drugs in food producing animals has always generated controversy regarding the issue of food safety. As an alternative to conventional treatment, diverse publication come pointing the promising therapeutic use of natural products (plants) to the treatment of several diseases that affect animal farming, despite data that indicate possible toxic effects and food security of these products have not yet been fully clarified. In this context, previously investigations describe the promising potential use of plants from Brazilian flora, like Copaifera oleoresins, in treatment for example fish parasitized by helminths, nevertheless scientific literature about chemical composition oleoresins indicate that some of these constituents may pose risks to the health of the consumer. Thus, the present project proposal aims at contributing with the evaluate of the potential use of crude oleoresin in fish cultivates (Piaractus mesopotamicus) and verify residual persistence of the principal chemical components of oleoresin applied, with emphasis on the quantification of substances with toxic effects already described in the literature, such as ent-agathic acid; for this, will be developed, optimized and validated analytical method employing the LC-MS techniques. The development of this project seeks to contribute to the study of food safety of natural products used in fish farming, as well as to suggest an alternative model in vivo to verify the toxic effects of substances from natural sources. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, JONAS JOAQUIM MANGABEIRA; CAMPANHARO, SARAH CHAGAS; PASCHOAL, JONAS AUGUSTO RIZZATO. Ethnoveterinary for food-producing animals and related food safety issues: A comprehensive overview about terpenes. COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, v. 20, n. 1, p. 48-90, JAN 2021. (19/06159-8, 17/15052-7, 18/05536-0, 12/18334-0)

DA SILVA, JONAS JOAQUIM MANGABEIRA; CAMPANHARO, SARAH CHAGAS; DA SILVA, AGNALDO FERNANDO BALDO; DE JESUS, RAPHAEL BARBETTA; FIGUEREDO, TAIS ALEXANDRA MARIO; PILARSKI, FABIANA; HELENO, VLADIMIR CONSTANTINO GOMES; PASCHOAL, JONAS AUGUSTO RIZZATO. Combination of extractive techniques followed by HPLC-MS/MS analysis to monitor ent-agathic acid in fish treated with Copaifera duckei Dwyer. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1224, p. 7-pg., 2023-05-26. (19/06159-8, 17/15052-7, 12/18334-0)

CAMPANHARO, SARAH CHAGAS; DA SILVA, AGNALDO FERNANDO BALDO; BLEUZEN, ANAIS; DA SILVA, JONAS JOAQUIM MANGABEIRA; DE FREITAS, LUCAS VICTOR PEREIRA; ASSANE, INACIO MATEUS; PILARSKI, FABIANA; PASCHOAL, JONAS AUGUSTO RIZZATO. The association of modified QuEChERS and DLLME to offer high analytical detectability to assess residual depletion profile of erythromycin in fish. Food Chemistry, v. 405, p. 8-pg., 2023-03-30. (12/18334-0, 19/06159-8, 17/15052-7, 18/05536-0, 19/22775-0, 21/03294-1)