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Cannabidiol effects on ethanol related disorders in rodents

Grant number: 17/21470-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2018
Effective date (End): December 31, 2018
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Sheila Antonagi Engi
Grantee:Everton Oliveira Santos
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:13/24986-2 - The role of neuronal ensembles in context-induced reinstatement of ethanol seeking: pharmacogenetic, optogenetic and molecular investigation, AP.JP

Abstract

Drug abuse is a worldwide public health problem and has achieved considerable proportions in recent years. Studies demonstrate that the cannabidiol features Ansiolíticas, Anti-psicóticas, antidepressant and neuroprotective properties, but little is known about how the exact mechanism of action of these properties is. There is evidence that cannabidiol treatment can reduce the consumption of other abuse drugs, such as cocaine and amphetamines. Despite the relevance of the theme, a broad review of the literature has not revealed the presence of studies that investigate the effects of treatment with cannabidiol in behavior related to ethanol dependence, such as acquisition and reinstallation of the behavior of Operating auto management. In this way, this project aims to investigate whether the treatment with cannabidiol: 1) decreases the consumption of ethanol in the animal model of the operating auto management; 2) prevents relapsing to ethanol using the animal model of the operating auto administration after exposure to ethanol in the steam chamber. (AU)