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Comparison between porcine acellular dermal matrix (Mucoderm®) versus connective tissue graft in the treatment of multiple gingival recessions associated with non-carious cervical lesion partially restored: randomized clinical trial

Grant number: 18/03284-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2018
Effective date (End): December 31, 2019
Field of knowledge:Health Sciences - Dentistry - Periodontology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Mauro Pedrine Santamaria
Grantee:Amanda Rossato
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

The literature indicates a high prevalence of multiple adjacent gingival recessions which are often associated with no-carious cervical lesion (NCCL), resulting, thus, to a combined defect. This condition has a different treatment prognosis comparing with a gingival recession without wearing surface associated and frequently needs a surgical-restorative approach to achieve better aesthetic e functional results.Clinical studies assessed different surgical-restorative treatment options to lead to single recessions associated with NCCL. However, although they are a common finding, insufficient evidence is available in the literature concerning about the treatment of multiple adjacent gingival recessions associated with non-carious cervical lesions and the optimal clinical protocol for the treatment of these lesions has not been established. Thus, the aim of this study is to compare two different multidisciplinary protocols by means of a randomized controlled clinical trial. For such purpose, forty patients with multiple adjacent gingival recessions associated with NCCL will be enrolled and randomly allocated to one of the following groups: test group (n=20), partial restoration of cervical lesion and modified coronally advanced flap for root coverage associated with porcine acellular dermal matrix (MCAF+PR+CM) and control group (n=20), partial restoration of cervical lesion and modified coronally advanced flap associated with connective tissue graft (MCAF+PR+CTG). The two groups will be compared regarding the clinical parameters, among which bleeding on probing (BOP), biofilm accumulation (IP), clinical attachment level (CAL), recession reduction (RecRed), the percentage of combined defect coverage (%CDC). Patient-reported outcomes as postsurgery sequelae, pain, discomfort, oral function, interference with daily activities, the decrease of dentin hypersensitive and aesthetic will be gathered. A professional assessment will be carried out regarding the aesthetics parameters. All these evaluations will be performed at the baseline and three and six months postoperatively. The parameters of height, width and depth of the cervical lesion (CLH, CLW and CLD), height and thickness of keratinized tissue (KTH and KTT), height and width of papillae (PH, PW), height of bone crest (HBN) and the margin position in the immediate postoperative period (MPIPP) will be placed as independent variables in a multiple linear regression model to evaluate their influence on the final outcome of the procedures. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIANA MIGUEL, MANUELA MARIA; FERREIRA FERRAZ, LAIS FERNANDA; ROSSATO, AMANDA; FARIA CINTRA, TUANA MENDONCA; MATHIAS-SANTAMARIA, INGRID FERNANDES; SANTAMARIA, MAURO PEDRINE. Comparison between connective tissue graft and xenogeneic acellular dermal matrix to treat single gingival recession: A data reanalysis of randomized clinical trials. Journal of Esthetic and Restorative Dentistry, v. N/A, p. 10-pg., . (21/00588-4, 12/14595-3, 14/00119-0, 18/03284-3)
MATHIAS-SANTAMARIA, INGRID FERNANDES; SILVEIRA, CAMILA AUGUSTO; ROSSATO, AMANDA; SAMPAIO DE MELO, MARY ANNE; BRESCIANI, EDUARDO; SANTAMARIA, MAURO PEDRINE. Single gingival recession associated with non-carious cervical lesion treated by partial restoration and coronally advanced flap with or without xenogenous collagen matrix: A randomized clinical trial evaluating the coverage procedures and restorative protocol. Journal of Periodontology, . (18/03284-3, 16/26154-2)
ROSSATO, AMANDA; MATHIAS-SANTAMARIA, INGRID FERNANDES; FERREIRA FERRAZ, LAIS FERNANDA; GOMEZ BAUTISTA, CRISTHIAN REYNALDO; VIANA MIGUEL, MANUELA MARIA; SANTAMARIA, MAURO PEDRINE. Xenogeneic Acellular Dermal Matrix for the Treatment of Multiple Gingival Recessions Associated with Partially Restored Noncarious Cervical Lesions. INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, v. 42, n. 6, p. 8-pg., . (18/03284-3)
SANTAMARIA, MAURO PEDRINE; ROSSATO, AMANDA; VIANA MIGUEL, MANUELA MARIA; FONSECA, MANUELA BAFINI; GOMEZ BAUTISTA, CRISTHIAN REYNALDO; MARCO, ANDREA CARVALHO; MATHIAS-SANTAMARIA, INGRID FERNANDES; FERREIRA FERRAZ, LAIS FERNANDA. Comparison of two types of xenogeneic matrices to treat single gingival recessions: A randomized clinical trial. Journal of Periodontology, . (18/03284-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ROSSATO, Amanda. Comparison between porcine acellular dermal matrix (Mucoderm®) versus connective tissue graft in the treatment of multiple adjacent gingival recessions associated with non-carious cervical lesion partially restored: randomized clinical trial. 2019. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Ciência e Tecnologia. São José dos Campos São José dos Campos.

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