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Effects of cystic fibrosis in the oral cavity pediatric patient

Grant number: 18/02725-6
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): August 01, 2018
Effective date (End): January 31, 2019
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Cristiane Yumi Koga Ito
Grantee:Laura Soares Souto Lepesqueur
Supervisor: Walter Luiz Siqueira
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
Research place: Western University , Canada  
Associated to the scholarship:15/23318-1 - Effects of cystic fibrosis on the oral cavity of pediatric patients, BP.DR


The purpose of the research project to be developed during the international internship is to investigate the impacts of cystic fibrosis (CF) on the salivary composition of pediatric patients by salivary proteome analyses. Hundred children aged from 3 to 20 years will be included in the study and will be divided into 3 groups: G1- 25 pediatric patients with CF, CFTR mutation detected and Shwachman-Kulczycki score between 100 and 71; G2- 25 pediatric patients with CF, CFTR mutation detected and Shwachman-Kulczycki score under 71; and fifty systematically healthy children, paired according to age and sex to the CF groups. Stimulated saliva will be collected. Aliquots of saliva will be preserved at -80 ° C until processing for the proteomic analysis. Salivary proteins profiles will be generated by nLC-ESI-MS / MS technique. The profiles obtained for CF patients (G1 and G2) will be compared to the paired control group. The results will be analyzed by appropriate statistical tests (±=0.05).

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