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Follow-up study of the cohorts of Campinas and Ermelino Matarazzo of the FIBRAs study: predictors and outcomes of fragility in the elderly in Brazil

Grant number: 18/06783-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2018
Effective date (End): April 30, 2019
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Monica Sanches Yassuda
Grantee:Gabriela Asenjo Seoanes
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:16/00084-8 - Longitudinal study of the Campinas and Ermelino Matarazzo cohorts of the FIBRA study: predictors and outcomes of frailty among the elderly in Brazil, AP.TEM


Fragility is a clinical syndrome associated with negative health outcomes. The study of the fragility among Brazilian elderly is of special relevance, since they live in different conditions of European and North American elderly for income, schooling, access to health and social opportunities. These differences may alter the configuration of this syndrome in Brazil, as well as its antecedents and outcomes. The aim of this study was to evaluate the follow-up after seven years of two cohorts of the elderly who were included in the population-based study FIBRA pole UNICAMP, with data collection performed between 2008 and 2009 in Campinas (n = 900) and Ermelino Matarazzo ( n = 384). It is intended to answer the following research questions: 1. Among the robust elderly in 2008/2009, how many have become pre-fragile and fragile after seven years and what factors, among a set of sociodemographic, psychological, social and health measures, predict embitterment ?; 2. Are fragility a nd pre-fragility identified in 2008/2009 in a portion of the original sample associated with health outcomes after seven years (eg death, immobility, functional dependency, dementia, hospitalization, others)?; 3. Among the robust, pre-frail and fragile elderly people in 2008/2009, who developed major or minor neurocognitive disorders and which factors, among a set of sociodemographic, psychological, social and health measures, predicted these conditions? Methods: Participants of the original sample will be contacted by letter and later by phone to identify the participant's current situation and possible home interview schedule. The original protocol of the FIBRA study will be reapplied, through adjustments, to collect sociodemographic data, health, neurocognitive and psychiatric profile, anthropometry, indicators of fragility, psychosocial characteristics and food consumption. The participant's family member will be interviewed for neurocognitive profile information and should be the primary informant if the participant is unable to participate. This longitudinal study should generate information on long-term predictors of frailty within the elderly in the baseline sample and could identify the fragility outcomes among the elderly identified as fragile or pre-frail. This research will provide information on intervenable factors that may attenuate or postpone negative health outcomes associated with frailty.