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Analysis of electrical synapses contribution in neuronal synchronization

Grant number: 17/18977-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2018
Effective date (End): May 31, 2020
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Alexandre Hiroaki Kihara
Grantee:Fernando da Silva Borges
Home Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated research grant:15/50122-0 - Dynamic phenomena in complex networks: basics and applications, AP.TEM

Abstract

In this project, using experimental results and computational modeling, we aimed to investigate the influence of gap junctions (GJ) channels on neuronal synchronization and we intend to study the effects of drugs on the attenuation of epileptic seizures. Electrophysiological records, both in vivo and in vitro, of the hippocampus and cortex of healthy rats and pilocarpine-induced status epilepticus(SE) rats will be performed. These results will be analyzed using statistical and modeling tools considering networks of adaptive exponential integrate-and-fire neurons. Firstly, simulations of healthy rat firing patterns will be done, as wellas analyzes of the effects of blocking GJ channels on previously simulated patterns, in order to observe the contribution of these channels in neuronal activity under physiological conditions. Then, similar simulations and analyzes will beperformed based on the neuronal activity observed in the condition of epileptic seizures, in order to verify the contribution of GJ channels in epilepsy. With these analysis we expect the elucidation of mechanisms involved with the generation of epileptic seizures, making possible the development of therapeutic strategies.

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PROTACHEVICZ, PAULO R.; BORGES, FERNANDO S.; LAMEU, EWANDSON L.; JI, PENG; IAROSZ, KELLY C.; KIHARA, ALEXANDRE H.; CALDAS, LBERE L.; SZEZECH JR, JOSE D.; BAPTISTE, MURILO S.; MACAU, ELBERT E. N.; ANTONOPOULOS, CHRIS G.; BATISTA, ANTONIO M.; KURTHSW, JUERGEN. Bistable Firing Pattern in a Neural Network Model. FRONTIERS IN COMPUTATIONAL NEUROSCIENCE, v. 13, APR 5 2019. Web of Science Citations: 1.
SANTOS, MOISES S.; PROTACHEVICZ, PAULO R.; IAROSZ, KELLY C.; CALDAS, IBERE L.; VIANA, RICARDO L.; BORGES, FERNANDO S.; REN, HAI-PENG; SZEZECH, JR., JOSE D.; BATISTA, ANTONIO M.; GREBOGI, CELSO. Spike-burst chimera states in an adaptive exponential integrate-and-fire neuronal network. Chaos, v. 29, n. 4 APR 2019. Web of Science Citations: 0.
MUGNAINE, MICHELE; REIS, ADRIANE S.; BORGES, FERNANDO S.; BORGES, RAFAEL R.; FERRARI, FABIANO A. S.; IAROSZ, KELLY C.; CALDAS, IBERE L.; LAMEU, EWANDSON L.; VIANA, RICARDO L.; SZEZECH, JR., JOSE D.; KURTHS, JUERGEN; BATISTA, ANTONIO M. Delayed feedback control of phase synchronisation in a neuronal network model. European Physical Journal-Special Topics, v. 227, n. 10-11, p. 1151-1160, NOV 2018. Web of Science Citations: 2.
LAMEU, E. L.; MACAU, E. E. N.; BORGES, F. S.; IAROSZ, K. C.; CALDAS, I. L.; BORGES, R. R.; PROTACHEVICZ, P. R.; VIANA, R. L.; BATISTA, A. M. Alterations in brain connectivity due to plasticity and synaptic delay. European Physical Journal-Special Topics, v. 227, n. 5-6, SI, p. 673-682, SEP 2018. Web of Science Citations: 1.
LAMEU, E. L.; YANCHUK, S.; MACAU, E. E. N.; BORGES, F. S.; IAROSZ, K. C.; CALDAS, I. L.; PROTACHEVICZ, P. R.; BORGES, R. R.; VIANA, R. L.; SZEZECH, JR., J. D.; BATISTA, A. M.; KURTHS, J. Recurrence quantification analysis for the identification of burst phase synchronisation. Chaos, v. 28, n. 8 AUG 2018. Web of Science Citations: 3.
PROTACHEVICZ, P. R.; BORGES, R. R.; REIS, A. S.; BORGES, F. S.; IAROSZ, K. C.; CALDAS, I. L.; LAMEU, E. L.; MACAU, E. E. N.; VIANA, R. L.; SOKOLOV, I. M.; FERRARI, F. A. S.; KURTHS, I; BATISTA, A. M.; LO, C-Y; HE, Y.; LIN, C-P. Synchronous behaviour in network model based on human cortico-cortical connections. Physiological Measurement, v. 39, n. 7 JUL 2018. Web of Science Citations: 3.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.