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Anti-cariogenic effect of a hybrid coating associated or not to sodium fluoride or sodium fluoride plus stannous chloride on enamel

Grant number: 18/06251-9
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): August 01, 2018
Effective date (End): July 31, 2019
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Taís Scaramucci Forlin
Grantee:Sávio José Cardoso Bezerra
Supervisor abroad: Anderson Takeo Hara
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Indiana University, United States  
Associated to the scholarship:17/13855-5 - Anti-erosive and anti-abrasive effect of a hybrid film associated or not with sodium fluoride or sodium fluoride and stannous chloride in enamel and dentin, BP.DR

Abstract

The aim of this study is incorporate fluoride, or the combination of fluoride and tin chloride, encapsulated in nano tubes of halloysite and bentonite, into a hybrid coating and later test the anti-caries preventive potential of these films on enamel. Enamel specimens (5 mm x 5 mm), obtained from bovine teeth, will be prepared. The enamel specimens will be treated with the polymeric coatings (n=10), then they will have their surface divided into two parts (5 mm x 2,5 mm each), one where the treatments will be applied and then submitted to the cariogenic challenge (under treatment), and the other that will be submitted only to the cariogenic challenge (adjacent to treatment). After, all the treated specimens will be fixed vertically in metal devices, and immersed in 24-well culture plates to be submitted to a cariogenic challenge, using a biofilm model for 5 days. The response variable will be the mineral content change, measured by transverse microradiography, and expressed by the total mineral loss and average lesion depth. Data will be statistically analyzed using appropriate methods (± = 0.05).