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Chemo-preventive properties of extracts from blueberries, jabuticabas and cinnamon isolated or combined with probiotics

Grant number: 18/05315-3
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): October 01, 2018
Effective date (End): September 30, 2019
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Engineering
Principal researcher:Carmen Sílvia Fávaro Trindade
Grantee:Augusto Tasch Holkem
Supervisor abroad: Monique Lacroix
Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
Research place: Institut National de la Recherche Scientifique (INRS), Canada  
Associated to the scholarship:15/19375-0 - Coencapsulation of probiotics and proanthocyanidin-rich extract obtained from cinnamon (Cinnamomum zeylanicum Blume), BP.DR


Colorectal cancer (CRC) is among the most frequent types in the world population. The increase in the development of this disease is mainly in eating habits. Evidence shows that the composition of the intestinal microbiota may be associated with the development of CRC and other dysbioses. Modulation of the gut by probiotics and phenolic compounds alone or in combination could positively influence the immune system and is beneficial in the preserving of CRC. The association of probiotics and phenolics presents great potential since some studies have suggested that there is a synergy among them. The objective of this project will be to investigate the chemoprotective effect of extracts from blueberries, jabuticabas and cinnamon isolated or together with probiotics against CRC cells development. The project will be carried out following antiproliferative, apoptosis, anti-radical and quinone reductase assays. No research addressing the chemoprevention effects of these extracts together with probiotics on CRC cells was found in the literature, which allows us to intuit that this is an innovative proposal.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HOLKEM, AUGUSTO TASCH; FAVARO-TRINDADE, CARMEN SILVIA. Potential of solid lipid microparticles covered by the protein-polysaccharide complex for protection of probiotics and proanthocyanidin-rich cinnamon extract. Food Research International, v. 136, OCT 2020. Web of Science Citations: 0.
SILVA, MARLUCI P.; THOMAZINI, MARCELO; HOLKEM, AUGUSTO T.; PINHO, LORENA S.; GENOVESE, MARIA I.; FAVARO-TRINDADE, CARMEN S. Production and characterization of solid lipid microparticles loaded with guarana (Paullinia cupana) seed extract. Food Research International, v. 123, p. 144-152, SEP 2019. Web of Science Citations: 2.

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