Effect of aerobic physical exercise and high fat diet on prostate of wild mouse and PPAR-± - / -: histopathological and molecular analysis

• Grant number: 18/05092-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2018
• End date: August 31, 2020
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Giovana Rampazzo Teixeira
• Grantee: Maria Eduarda de Almeida Tavares
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

The prostate is an accessory gland of the male genital system, important for producing 30% of the seminal fluid. Factors such as the high fat diet, smoking, alcohol and lifestyle habits can affect prostate homeostasis, cardiac diseases and cancer. Alcohol abuse, smoking and physical inactivity are other factors for the progress of cancers, including prostate cancer. The aerobic physical exercise has as an auxiliary function the loss of weight and reduction o and metabolic changes brought on by health problems such as obesity, diabetes, pro-inflammatory cytokines, as a non-pharmacological agent in disease prevention. In this way, this aim of this study will verify the participation of the gene transcription factor PPAR-±, as a possible key regulator, protease from physical exercise through certain immunometolic prostates, from mice shipped with a standard diet and high fat diet. We will seek answers to the emotional practices of physical exercise in the prostate. The animals were underwent into 8 groups, after euthanasia, the prostate was collected and processed by histological and immunohistochemistry testes. For the statistical analysis, the program SigmaPlot 12.0 will be used, which will be used for the statistical analysis, adopting a level of significance of p> 0.05%. The results can be found in animals that ate a higher body weight hyperlipid diet, compared to animals that ate a standard diet. And that if wild groups are compared with knockout in PPAR-±, wild animals are significantly heavier.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAVARES, MARIA EDUARDA ALMEIDA; VERAS, ALLICE SANTOS CRUZ; THORPE, HAYLEY HOPE ALLYSSA; BAPTISTA, DANILO BIANCHINI; TEIXEIRA, GIOVANA RAMPAZZO. Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice. Prostaglandins & Other Lipid Mediators, v. 163, p. 13-pg., 2022-12-01. (18/05092-4)